FAM129C

Niban-like protein 2.^[1](NLP2) is a protein that in humans is encoded by the FAM129C^[1] gene. Paralogs of this gene include FAM129A, and FAM129B.^[2] Its aliases include B-Cell Novel Protein 1 (BCNP1), and Family with Sequence Similarity 129 Member C (FAM129C).^[3][4]

Gene

The FAM129C gene is 30,538

True orthologs of FAM129C seem to be highly conserved in mammals, reptiles, marsupials, bony and cartilaginous fish. The most distant ortholog of FAM129C were found to be in a cellular slime mould, Polysphondyllum pallidum, and even a species of barley, Hordeum vulgare.

Gene Expression

In normal tissues, the highest expression was in

In the human GEO profile, FAM129C appears to be expressed at lower levels in tissues with dilated cardiomyopathy by almost 50% when compared to non-failing septum tissue.^[10] This may mean that FAM129C plays a role in non-failing heart tissue. Another condition in which FAM129C is significantly down-regulated is with the wild-type genotype hippocampal tissue of Rubinstein-Taybi compared with the p300 +/- genotype.^[11] People with this condition have an increased risk of developing noncancerous and cancerous tumors such as leukemia and lymphoma

Protein

The

The predicted tertiary structure for NLP2 shows the FAM129C PH domain. There are seven predicted β sheets at the N terminus.[8]^[13] This will form the tertiary structure of the pleckstrin homology domain.^[8]

Protein Post-Modification

Transmembrane domains, peptide cleavage sites, or strong glycosylation sites were not predicted for NLP2.^{[14][15][16][17][18][19]} A total of 32 likely phosphorylation sites were predicted on Serine (25,) Threonine (5), and Tyrosine (2).^[20]

References