Fibronectin type III domain
| Fibronectin type III domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CDD | cd00063 | ||||||||
| Membranome | 66 | ||||||||
| |||||||||
The Fibronectin type III domain is an evolutionarily conserved
disulfide bonding
present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.
Human proteins containing this domain
CNTN4; CNTN5
;
;
EPHA1; EPHA10
;
EPHB1
;
;
;
;
IL12RB1
;
IL7R
;
LEPR
;
;
MYBPC3; MYBPH
;
NCAM2; NEO1
;
OSMR; PHYHIP
;
PHYHIPL; PRLR; PRODH2; PTPRB; PTPRC; PTPRD; PTPRF; PTPRG;
PTPRH; PTPRJ; PTPRK; PTPRM; PTPRO; PTPRS; PTPRT; PTPRU;
PTPRZ1; PTPsigma; PUNC; RIMBP2; ROBO1; ROBO2; ROBO3; ROBO4;
ROS1; SDK1; SDK2; SNED1; SORL1; SPEG; TEK; TIE1;
;
TRIM9; TTN; TYRO3; UMODL1; USH2A; VASN; VWA1; dJ34F7.1;
fmi;
See also
- Monobodiesare engineered (synthetic) antibody mimetics based on a fibronectin type III domain (specifically, the 10th FN3 domain of human fibronectin). Monobodies feature either diversified loops or diversified strands of a flat beta-sheet surface, which serve as interaction epitopes. Monobody binders have been selected a wide variety of target molecules, and have expanded beyond the potential range of binding interfaces observed in both natural and synthetic antibodies.
References
- Bazan JF (September 1990). "Structural design and molecular evolution of a cytokine receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 87 (18): 6934–8. PMID 2169613.
- Little E, Bork P, Doolittle RF (December 1994). "Tracing the spread of fibronectin type III domains in bacterial glycohydrolases". Journal of Molecular Evolution. 39 (6): 631–43. S2CID 11909704.
- Kornblihtt AR, Umezawa K, Vibe-Pedersen K, Baralle FE (July 1985). "Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene". The EMBO Journal. 4 (7): 1755–9. PMID 2992939.