PTPRG
| PTPRG | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
| ||
| Sources:Amigo / QuickGO | |||
Ensembl |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 3: 61.56 – 62.3 Mb | n/a | |||||||
| PubMed search | [2] | [3] | |||||||
| View/Edit Human | View/Edit Mouse |
Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.[4][5]
The protein encoded by this gene is a member of the
mitotic cycle
, and oncogenic transformation.
This PTP possesses an extracellular region, a single
lung carcinoma, thus is thought to be a candidate tumor suppressor gene.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000144724 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1711217.
- ^ a b "Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G".
Further reading
- Kaplan R, Morse B, Huebner K, et al. (1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7000–4. PMID 2169617.
- Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases". EMBO J. 9 (10): 3241–52. PMID 2170109.
- Latif F, Tory K, Modi W, et al. (1993). "A MspI polymorphism and linkage mapping of the human protein-tyrosine phosphatase G (PTPRG) gene". Hum. Mol. Genet. 2 (1): 91. PMID 7683956.
- Barnea G, Silvennoinen O, Shaanan B, et al. (1993). "Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases". Mol. Cell. Biol. 13 (3): 1497–506. PMID 8382771.
- Kastury K, Ohta M, Lasota J, et al. (1997). "Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation". Genomics. 32 (2): 225–35. PMID 8833149.
- van Niekerk CC, Poels LG (1999). "Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors". Cancer Lett. 137 (1): 61–73. PMID 10376795.
- Kawachi H, Tamura H, Watakabe I, et al. (1999). "Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family". Brain Res. Mol. Brain Res. 72 (1): 47–54. PMID 10521598.
- Liu S, Kulp SK, Sugimoto Y, et al. (2002). "Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents". Breast Cancer Res. Treat. 71 (1): 21–35. S2CID 6175175.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Liu S, Sugimoto Y, Kulp SK, et al. (2003). "Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha". Anticancer Res. 22 (6C): 3917–23. PMID 12553013.
- Liu S, Sugimoto Y, Sorio C, et al. (2004). "Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7". Oncogene. 23 (6): 1256–62. PMID 14676845.
- van Doorn R, Zoutman WH, Dijkman R, et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73". J. Clin. Oncol. 23 (17): 3886–96. PMID 15897551.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. PMID 16335952.
PDB gallery | |
|---|---|
|
 | This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it. |