Finnish heritage disease

Source: Wikipedia, the free encyclopedia.

A Finnish heritage disease is a genetic disease or disorder that is significantly more common in people whose ancestors were ethnic

Northern Sweden (Meänmaa) and Northwest Russia (Karelia and Ingria). There are 36 rare diseases regarded as Finnish heritage diseases.[1] The diseases are not restricted to Finns; they are genetic diseases with far wider distribution in the world, but due to founder effects and genetic isolation
they are more common in Finns.

Within

Sámi and Karelians other than Finnish Karelians. It is attributed to a population bottleneck among ancestors of modern Finns, estimated to have occurred about 4000 years ago, presumably when populations practicing agriculture and animal husbandry arrived in Finland.[3]

In Finland about one in five persons carries a gene defect associated with at least one Finnish heritage disease, and about one in 500 children born is affected.

recessives, so that if both the mother and father carry the same defect, the chance that their child will have the associated disease is 1 in 4. The molecular genetics of many of these diseases have been determined, enabling genetic testing, prenatal testing, and counseling. This has raised questions of bioethics and eugenics.[5]

Finnish heritage disease types

There are 36 identified Finnish heritage diseases:[6][7]

Out of these, three are rare causes of dwarfism: cartilage–hair hypoplasia, diastrophic dysplasia and Mulibrey nanism.

Four genetically distinct subtypes of

CLN3, CLN5, and CLN8.[8] Names for conditions associated with these subtypes include infantile neuronal ceroid lipofuscinosis, Jansky–Bielschowsky disease and northern epilepsy syndrome. As of 2001, CLN5 and CLN8 had been reported almost exclusively in Finland.[8]

Meckel syndrome type 1 (MKS1[9]), a lethal condition, is known in 48 Finnish families.[10]

Other genetic diseases

The

European Organization for Rare Diseases (EURORDIS) estimates that there are between 5,000 and 7,000 distinct rare diseases, affecting between 6% and 8% of the population of the European Union.[11]
The majority of genetic diseases reported in Finland are not part of the Finnish disease heritage and their prevalence is not higher in Finland than worldwide.

Some genetic diseases are disproportionately rare in Finns. These include cystic fibrosis and phenylketonuria. In Finland, about 1 in 80 persons are carriers of a cystic fibrosis mutation, compared with an average of 1 in 25 elsewhere in Europe.[12]

Genetic history

Based on molecular data, a population bottleneck among ancestors of modern Finns is estimated to have occurred about 4000 years ago.[3] This bottleneck resulted in exceptionally low diversity in the Y chromosome, estimated to reflect the survival of just two ancestral male lineages.[13][14] The distribution of Y chromosome haplotypes within Finland is consistent with two separate founding settlements, in eastern and western Finland.[15] The Finnish disease heritage has been attributed to this 4000-year-old bottleneck.[3] The geographic distribution and family pedigrees associated with some Finnish heritage disease mutations has linked the enrichment in these mutations to multiple local founder effects, some associated with a period of "late settlement" in the 16th century (see History of Finland).[16]

Etymology

Although the concept is older, the English term "Finnish disease heritage" first appears in the medical literature in the 1990s. One of the earliest uses is in the translated title of a 1994 medical article,[17] soon followed by others.[3][18]

See also

References

  1. S2CID 26741302
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  2. PMID 19367325
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  3. ^
    PMID 8876258
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  4. S2CID 22368642
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  5. ISBN 0-415-35407-2
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  6. ^ "The Finnish Disease Heritage". FinDis. Archived from the original on 13 January 2017. Retrieved 4 March 2018.
  7. ^ "Diseases". FinDis. Retrieved 4 March 2018.
  8. ^
    ISBN 0-12-017645-9
    . page 125
  9. S2CID 11815792
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  10. PMID 6486167
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  11. ^ "Rare Diseases: Understanding This Public Health Priority" (PDF). European Organisation for Rare Diseases (EURORDIS). November 2005. Retrieved 16 May 2009.
  12. PMID 11813900
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  13. PMID 10229384
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  14. PMID 10352935
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  15. PMID 9545401
    .
  16. PMID 10469845
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  17. PMID 8542820
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  18. S2CID 29999767
    .
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