Glycylpeptide N-tetradecanoyltransferase 2
| Human N-myristoyltransferase 2 | |||||||||
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 Human N-myristoyltransferase isoform 2 (NMT2) (based on PDB: 4c2x) | |||||||||
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| Symbol | NMT2 | ||||||||
| Pfam | PF01233 | ||||||||
| InterPro | IPR022676 | ||||||||
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| NMT2 | ||||||||||||||||||||||||||||||||||||||||
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| Wikidata | ||||||||||||||||||||||||||||||||||||||||
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Glycylpeptide N-tetradecanoyltransferase 2 known also as N-myristoyltransferase, is an enzyme (EC: 2.3.1.97) that in humans is encoded by the NMT2 gene.[5]
Function
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal
signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The 496-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.[6]
Interactions
NMT2 has been shown to
interact
with:
See also
- N-myristoyltransferase 1
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000152465 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026643 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9506952.
- PMID 25255805.
- PMID 17390089.
- PMID 19746168.
Further reading
- Kolluri SK, Balduf C, Hofmann M, Göttlicher M (2002). "Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2". Cancer Res. 61 (23): 8534–9. PMID 11731439.
- Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW (2014). "Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach". Nat Chem. 6 (2): 112–21. PMID 24451586.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)
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