HINT2
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Histidine triad nucleotide binding protein 2 (HINT2) is a
Structure
As a member of the histidine triad nucleotide-binding (Hint) protein family, which is a subfamily of the histidine triad (HIT) family, HINT2 contains a conserved histidine and HIT sequence motif (His-X-His-X-His-X-X), and the latter two histidines contribute to a
The 163-N-terminal corresponds to a predicted mitochondria import signal.[8]
Function
HINT2 is a member of the HIT superfamily and Hint subfamily, which are characterized as
apoptotic function in hepatocytes and other non-steroidogenic cells, though the exact mechanism remains unclear.[7]
Clinical significance
Hint2, one of the three members of the Hint family of proteins, is localized to
cytoplasmic
Ca2+, oscillations can occur. Mitochondria also affect cytoplasmic Ca2+ signals. They can both buffer cytosolic Ca2+ changes (7 and 8) and release Ca2+. At rest, intramitochondrial ([Ca2+]m) and cytosolic Ca2+ concentration ([Ca2+]i) are similar, of the order of 100 nM (9).
The Hint family has been implicated in tumor suppression.heart attacks) through calcium homeostasis.
In particular, HINT2 is also observed to be upregulated in
colon cancer cells, while it is downregulated in hepatocellular carcinoma and endometrial cancer. Its exact role in tumor suppression remains unknown, though studies suggest it may promote apoptosis in hepatocellular carcinoma and endometrial cancer.[6][7][8][9] In double knockout Hint2 mice, higher acylation and morphological alterations were observed in the mitochondria, suggesting that Hint2 may regulate glucose and lipid metabolism.[10]
Interactions
Currently, HINT2 has no known
protein-protein interaction partners.[6]
See also
- Histidine triad nucleotide-binding protein 1(HINT1)
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000137133 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028470 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: HINT2 histidine triad nucleotide binding protein 2".
- ^ PMID 23659632.
- ^ PMID 18653718.
- ^ PMID 16762638.
- ^ PMID 23682076.
- S2CID 28755223.