HLA-C
Ensembl |
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| RefSeq (protein) |
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| Location (UCSC) | Chr 6: 31.27 – 31.27 Mb | n/a | |||||||
| PubMed search | [2] | n/a | |||||||
| View/Edit Human | |||
HLA-C (Human Leukocyte Antigen-C) belongs to the MHC
class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin
. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.
HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.
Disease associations
By serotype
Cw1:
multinodular goiters[3]
By allele
C*16:
B-cell chronic lymphocytic leukemia[4]
Nomenclature
C*01
- Cw1 serotype: C*01:02 and C*01:09
- Cw11
- C*01:04 to *01:08
C*02
- Cw2 serotype: C*02:02 and *02:08
- C*02:03 to *02:07, and 02:09
C*03
- Cw9 serotype: C*03:03
- Cw10 serotype: C*03:02, *03:04, and *03:06
- Cw3 serotype: C*03:07
- C*03:05 and 03:08
C*04
- Cw4 serotype: C*0401, *0407, and *0410
C*05
- Cw5 serotype: C*05:01 and *05:02
- C*05:03 to *05:06 and *05:08 to *05:10
C*06
- Cw6 serotype: C*06:02 and *06:05
- C*06:03, *06:04 and *06:06 to *06:11
C*07
- Cw7 serotype: C*07:01 to *07:06, *07:12, *07:14, *07:16
- C*07:07 to *07:11, *07:13, *07:15, and *07:17 to *07:29
C*08
- Cw8 serotype: C*08:01, *08:02 and *08:03
- C*08:05 to *08:12
Others
- C*12:02 to *12:15
- C*14:02 to *14:05
- C*15:01 to *15:11
- C*16:01 to *16:06
- C*17:01 to *17:03
- C*18:01 and *18:02
Common haplotype
Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)
Interactions
HLA-C has been shown to
interact
with:
References
- ^ a b c ENSG00000233841, ENSG00000228299, ENSG00000225691, ENSG00000206435, ENSG00000237022, ENSG00000206452 GRCh38: Ensembl release 89: ENSG00000204525, ENSG00000233841, ENSG00000228299, ENSG00000225691, ENSG00000206435, ENSG00000237022, ENSG00000206452 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 16490887.
- S2CID 23018830.
- PMID 12454284.
- PMID 11163076.
- PMID 9768753.
- S2CID 24707532.
- PMID 21270408.
Further reading
- Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. PMID 11463741.
- Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. S2CID 33749514.
- Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. PMID 12836198.
- Leavitt SA, SchOn A, Klein JC, Manjappara U, Chaiken IM, Freire E (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm". Curr. Protein Pept. Sci. 5 (1): 1–8. PMID 14965316.
- Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (2004). "HIV/SIV escape from immune surveillance: focus on Nef". Curr. HIV Res. 2 (2): 141–51. PMID 15078178.
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94. PMID 15638726.
- Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell". Current HIV/AIDS Reports. 1 (1): 47–53. S2CID 34731265.
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