HNRNPC
| HNRNPC | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
| View/Edit Human | View/Edit Mouse |
Heterogeneous nuclear ribonucleoproteins C1/C2 is a protein that in humans is encoded by the HNRNPC gene.[5][6]
It is abnormally expressed in fetuses of both
Function
This gene belongs to the subfamily of ubiquitously expressed
(VDR).[8][9][10] This relationship is disrupted by elevated HNRNPC, causing a form of hereditary vitamin D-resistant rickets (HVDRR) in both humans[8] and non-human primates.[11] The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Species-specific tetramerization of HNRNPC subunits is important to its nucleic acid binding, whereby over-expression of major human HNRNPC subunits in mouse osteoblastic cells confers vitamin D resistance.[12] Multiple transcript variants encoding at least two different isoforms have been described for this gene.[6]
Interactions
HNRNPC has been shown to
Grb2.[13]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000092199 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060373 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 3457372.
- ^ a b "Entrez Gene: HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2)".
- S2CID 206362532.
- ^ PMID 21123297.
- PMID 17071612.
- PMID 21236284.
- S2CID 25970432.
- PMID 25506471.
- PMID 9516488.
Further reading
- Görlach M, Wittekind M, Beckman RA, Mueller L, Dreyfuss G (1992). "Interaction of the RNA-binding domain of the hnRNP C proteins with RNA". EMBO J. 11 (9): 3289–95. PMID 1380452.
- Wittekind M, Görlach M, Friedrichs M, Dreyfuss G, Mueller L (1992). "1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins". Biochemistry. 31 (27): 6254–65. PMID 1385725.
- Burd CG, Swanson MS, Görlach M, Dreyfuss G (1990). "Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9788–92. PMID 2557628.
- Merrill BM, Barnett SF, LeStourgeon WM, Williams KR (1989). "Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles". Nucleic Acids Res. 17 (21): 8441–9. PMID 2587210.
- Swanson MS, Nakagawa TY, LeVan K, Dreyfuss G (1987). "Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins". Mol. Cell. Biol. 7 (5): 1731–9. PMID 3110598.
- Sébillon P, Beldjord C, Kaplan JC, Brody E, Marie J (1995). "A T to G mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased hnRNP C interaction". Nucleic Acids Res. 23 (17): 3419–25. PMID 7567451.
- Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Huang M, Rech JE, Northington SJ, Flicker PF, Mayeda A, Krainer AR, LeStourgeon WM (1994). "The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles". Mol. Cell. Biol. 14 (1): 518–33. PMID 8264621.
- Hamilton BJ, Nagy E, Malter JS, Arrick BA, Rigby WF (1993). "Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences". J. Biol. Chem. 268 (12): 8881–7. PMID 8473331.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Romero F, Ramos-Morales F, Domínguez A, Rios RM, Schweighoffer F, Tocqué B, Pintor-Toro JA, Fischer S, Tortolero M (1998). "Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA". J. Biol. Chem. 273 (13): 7776–81. PMID 9516488.
- Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. S2CID 585778.
- Sella O, Gerlitz G, Le SY, Elroy-Stein O (1999). "Differentiation-Induced Internal Translation of c-sis mRNA: Analysis of the cis Elements and Their Differentiation-Linked Binding to the hnRNP C Protein". Mol. Cell. Biol. 19 (8): 5429–40. PMID 10409733.
- Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N, Gorospe M (2000). "HuR Regulates p21 mRNA Stabilization by UV Light". Mol. Cell. Biol. 20 (3): 760–9. PMID 10629032.
- Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–90. PMID 10964780.
- Shahied L, Braswell EH, LeStourgeon WM, Krezel AM (2001). "An antiparallel four-helix bundle orients the high-affinity RNA binding sites in hnRNP C: a mechanism for RNA chaperonin activity". J. Mol. Biol. 305 (4): 817–28. PMID 11162094.
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.
- Stone JR, Collins T (2002). "Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cells". J. Biol. Chem. 277 (18): 15621–8. PMID 11877401.
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