Hanneke Jansen

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Johanna Maria "Hanneke" Jansen is a computational chemist working at Novartis on multiple drug targets. She previously worked at Astra and at Chiron Corporation.^[1]

Education

Jansen received her doctoral degree from the University of Groningen (The Netherlands) in 1995, studying computational medicinal chemistry. Her dissertation topic^[2] concerned 3D modeling of the melatonin receptor, including work on synthesizing and separating analytes^[3][4] to probe its chemistry. She completed a postdoctoral fellowship at Uppsala University in 1997. Her work there related to modeling receptor interactions^[5] of drug leads to judge their serotonergic or dopaminergic activities.

Research

Much of Jansen's oeuvre uses in silico methods to study receptor biology, drug design, and drug-protein interactions. An early study (2000) while she was employed at Chiron looked at conformations of the anti-cancer treatment Taxol in nonpolar environments.^[6]

In a 2012 commentary for Future Medicinal Chemistry, Jansen led a team of distinguished computational chemists in a call to action, namely that standardized data sets be used across the industry, and that sharing program code between groups at different companies and institutions should be mandated.^[7]

A 2017 open-access study in