Trypanosoma cruzi
Trypanosoma cruzi | |
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Trypanosoma cruzi in human blood Giemsa stain. They are typically seen as a C-shape and have a more pronounced kinetoplast compared to other species. | |
Scientific classification | |
Domain: | Eukaryota |
Phylum: | Euglenozoa |
Class: | Kinetoplastea |
Order: | Trypanosomatida |
Family: | Trypanosomatidae |
Genus: | Trypanosoma |
Species: | T. cruzi
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Binomial name | |
Trypanosoma cruzi |
Trypanosoma cruzi is a species of
Etymology
The specific name "cruzi" is an honor to Brazilian scientist Oswaldo Cruz, who taught discoverer Carlos Chagas.[4]
Life cycle
The Trypanosoma cruzi life cycle starts in an animal reservoir, usually mammals, wild or domestic, including humans. A triatomine bug serves as the vector. While taking a blood meal, it ingests T. cruzi. In the triatomine bug (the principal species of which in terms of parasite transmission to humans being
Pathophysiology
Trypanosomiasis in humans progresses with the development of the trypanosome into a
The acute form of trypanosomiasis is usually unnoticed, although it may manifest itself as a localized swelling at the site of entry. In this form appears elevated parasitism, myocarditis, and changes in the myocardial gene expression. The chronic form may develop 30 to 40 years after infection and affect internal organs (e.g., the
Acute cases are treated with nifurtimox and benznidazole, but no effective therapy for chronic cases is currently known.[citation needed]
Cardiac manifestations
Researchers of Chagas’ disease have demonstrated several processes that occur with all cardiomyopathies. The first event is an inflammatory response. Following inflammation, cellular damage occurs. Finally, in the body's attempt to recover from the cellular damage, fibrosis begins in the cardiac tissue.[14]
Another cardiomyopathy found in nearly all cases of chronic Chagas’ disease is thromboembolic syndrome. Thromboembolism describes thrombosis, the formation of a clot, and its main complication is embolism, the carrying of a clot to a distal section of a vessel and causing blockage there. This occurrence contributes to the death of a patient by four means: arrhythmias, stasis secondary to cardiac dilation, mural endocarditis, and cardiac fibrosis. These thrombi also affect other organs such as the brain, spleen and kidney.[15]
Myocardial biochemical response
Subcellular findings in murine studies with induced T. cruzi infection revealed that the chronic state is associated with the persistent elevation of phosphorylated (activated) extracellular-signal-regulated kinase (
Rhythm abnormalities
Conduction abnormalities are also associated with T. cruzi. At the base of these conduction abnormalities is a depopulation of parasympathetic neuronal endings on the heart. Without proper parasympathetic innervations, one could expect to find not only chronotropic but also inotropic abnormalities. It is true that all inflammatory and non-inflammatory heart disease may display forms of parasympathetic denervation; this denervation presents in a descriptive fashion in Chagas’ disease. It has also been indicated that the loss of parasympathetic innervations can lead to sudden death due to a severe cardiac failure that occurs during the acute stage of infection.[17]
Another conduction abnormality presented with chronic Chagas’ disease is a change in ventricular repolarization, which is represented on an electrocardiogram as the T-wave. This change in repolarization inhibits the heart from relaxing and properly entering diastole. Changes in the ventricular repolarization in Chagas’ disease are likely due to myocardial ischemia. This ischemia can also lead to fibrillation. This sign is usually observed in chronic Chagas’ disease and is considered a minor electromyocardiopathy.[18]
Epicardial lesions
Villous plaque is characterized by exophytic
Motility
When mammalian cells are present, trypomastigotes move in a sub diffusive fashion in short periods of time, but under control conditions their motion is diffusive.
Parasites increase their mean speed; they explore smaller areas at short time scales and show a preference to be located nearby cells’ periphery. The extent of these changes depends on the cell type. Therefore, T. cruzi trypomastigotes can sense mammalian cells and modify their motility patterns to prepare themselves for infection.[12]
Parasite reorientation
Epimastigotes, which are the culture forms of T. cruzi, swim in the direction of their flagellum, due to tip-to-base symmetrical flagellar beats, that are interrupted by base-to-tip highly asymmetric beats. Switching between both beating modes facilitates parasite reorientation, allowing many movements and trajectories. Epimastigote motility is characterized by alternation of quasi-rectilinear and restricted and complex paths.[12]
Invasion efficiency
The invasion efficiency is positively correlated with the average parasite mean speed, and negatively correlated with the mean square displacement (MSD). Therefore, the motility modifications undergone by the parasites in the presence of mammalian cells may be functionally related to the cell invasion process.
Moreover, different parasite strains infect different tissues with a variable invasion efficiency, due to the high genetic and phenotypic variability found among T. cruzi strains. T. cruzi trypomastigotes are capable of sensing mammalian cells to a different degree, depending on the cell type, and can modify their motility patterns to increase their invasion efficiency.[12]
Virulence chemistry
T. cruzi does not produce prostaglandins itself. Instead Pinge-Filho et al. 1999 finds that the parasite induces
Epidemiology
T. cruzi transmission has been documented in the Southwestern U.S., and warming trends may allow vector species to move north. U.S. domestic and wild animals are reservoirs for T. cruzi. Triatomine species in the southern U.S. have taken human blood meals, but because triatomines do not favor typical U.S. housing, risk to the U.S. population is very low.[21]
Chagas' disease's geographical occurrence happens worldwide but high-risk individuals include those who don't have access to proper housing. Its reservoir is in wild animals but its vector is a
Over 130 species can transmit this parasite[22]
Six taxonomic subunits are recognised.[23]
Clinical
The incubation period is five to fourteen days after a host comes in contact with feces. Chagas disease undergoes two phases, which are the acute and the chronic phase. The acute phase can last from two weeks to two months but can go unnoticed because symptoms are minor and short-lived. Symptoms of the acute phase include swelling, fever, fatigue, and diarrhea. The chronic phase causes digestive problems, constipation, heart failure, and pain in the abdomen. [citation needed]
Diagnostic methods include microscopic examination, serology, or the isolation of the parasite by inoculating blood into a guinea pig, mouse, or rat.[citation needed]
No vaccines are available. The most used method for epidemiological management and disease prevention resides within vector control,[24] mainly by the use of insecticides and taking preventative measures such as applying bug repellent on the skin, wearing protective clothing, and staying in higher quality hotels when traveling. Investing in quality housing would be ideal to decrease risk of contracting this disease.[25]
Genetic exchange
Genetic exchange has been identified among field populations of T. cruzi.[26] This process appears to involve genetic recombination as well as a meiotic mechanism. Despite the capability for sexual reproduction, natural populations of T. cruzi exhibit clonal population structures. It appears that frequent sexual reproduction events occur primarily between close relatives resulting in an apparent clonal population structure.[27]
See also
- List of parasites (human)
References
- ^ Chagas, C. (1909). "Neue Trypanosomen: Vorläufige mitteilung" [New trypanosome. Preliminary communication]. Archiv für Schiffs-und Tropenhygiene (in German). 13: 120–122.
- ^ Chagas, Carlos (1909). "Nouvelle espèce de trypanosomiase humaine" [New species of human trypanosomiasis] (PDF). Bulletin de la Société de Pathologie Exotique (in French). 2 (6): 304–307.
- ^ Chagas, C. (1909). "Nova especie morbida do homem, produzida por um Trypanozoma (Trypanozoma cruzi): nota prévia" [New morbid species of man, produced by a Trypanozoma (Trypanozoma cruzi): previous note]. Brazil-Medico (in French). 23 (16): 161.
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External links
- "American Trypanosomiasis (Trypanosoma cruzi)". DPDx—Laboratory Identification of Parasitic Diseases of Public Health Concern. Centers for Disease Control and Prevention. 29 November 2013.
- "Trypanosoma cruzi". NCBI Taxonomy Browser. 5693.