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Protein-coding gene in the species Homo sapiens
IGK Identifiers Ensembl
UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) n/a n/a PubMed search[1] n/a
Wikidata Immunoglobulin kappa locus , also known as IGK@ , is a region on the p arm of human
antibodies (or immunoglobulins).
[2] In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region.[3] V(D)J recombination to generate a diverse repertoire of immunoglobulins.
Genes The immunoglobulin kappa locus contains the following genes:
IGKC : immunoglobulin kappa constantIGKJ@: immunoglobulin kappa joining group
IGKJ1, IGKJ2, IGKJ3, IGKJ4, IGKJ5
IGKV@: immunoglobulin kappa variable group
IGKV1-5, IGKV1-6, IGKV1-8, IGKV1-9, IGKV1-12, IGKV1-16, IGKV1-17, IGKV1-27, IGKV1-33
IGKV1D-8, IGKV1D-12, IGKV1D-13, IGKV1D-16, IGKV1D-17, IGKV1D-22, IGKV1D-27, IGKV1D-32, IGKV1D-33, IGKV1D-39, IGKV1D-43
IGKV2-24, IGKV2-28, IGKV2-30, IGKV2-40
IGKV2D-26, IGKV2D-28, IGKV2D-29, IGKV2D-30, IGKV2D-40
IGKV3-11, IGKV3-15, IGKV3-20
IGKV3D-7, IGKV3D-11, IGKV3D-20
IGKV4-1
IGKV5-2
and a number of non-functional and pseudogenes References
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .. ^ Male, D., Brostoff, J., Roth, D.B., & Roitt, I. 2006. Immunology. 7th ed., Canada: Elsevier Limited
Further reading
