Interstitial granulomatous dermatitis with arthritis
| Interstitial granulomatous dermatitis with arthritis | |
|---|---|
| Other names | Ackerman dermatitis syndrome, IGDA |
| Specialty | Dermatology |
Interstitial granulomatous dermatitis with arthritis (IGDA) or Ackerman dermatitis syndrome is a skin condition that most commonly presents with symmetrical round-to-oval red or violet plaques on the flanks, armpits, inner thighs, and lower abdomen.[1]
Signs and symptoms
Interstitial granulomatous dermatitis with arthritis commonly presents with symmetrical round-to-oval red or violet plaques on the flanks, armpits, inner thighs, and lower abdomen.[1] The arthritis that coexists with these skin lesions may develop years, months, or even years before the cutaneous lesions first manifest. The symmetrical nature of the joint involvement is evident, frequently affecting the fingers, elbows, wrists, and shoulders.[2]
Causes
Certain medications, including
Diagnosis
This entity has a unique histopathology that is characterized by a diffuse, dense inflammatory infiltrate that is primarily made up of histiocytes within the reticular dermis. Palisades are formed by small foci of histiocytes and degenerated collagen. Neutrophils and eosinophils may be found in the infiltrate in addition to other things. Vasculitis and mucin deposition are not anticipated.[2]
Treatment
There is still uncertainty surrounding the suggested therapies for IGDA.
See also
- Skin lesion
References
Further reading
- CROWSON, A (2004). "Interstitial granulomatous dermatitis with arthritis". Human Pathology. 35 (7). Elsevier BV: 779–780. PMID 15257538.
- Schanz, Stefan (January 1, 2012). "Interstitial Granulomatous Dermatitis With Arthritis Responding to Tocilizumab". Archives of Dermatology. 148 (1). American Medical Association (AMA): 17–20. PMID 22250229.