Ionomycin

Source: Wikipedia, the free encyclopedia.
Ionomycin
Names
IUPAC name
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-Dihydroxy-22-{(2S,2′R,5S,5′S)-5′-[(1R)-1-hydroxyethyl]-2,5′-dimethyloctahydro-2,2′-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoic acid
Identifiers
3D model (
JSmol
)
ChEMBL
ChemSpider
ECHA InfoCard
 100.121.228 Edit this at Wikidata
UNII
  • InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1 ☒N
    Key: PGHMRUGBZOYCAA-ADZNBVRBSA-N ☒N
  • InChI=1/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
    Key: PGHMRUGBZOYCAA-ADZNBVRBBY
  • C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\O
Properties
C41H72O9
Molar mass 709.0050 g/mol
Solubility insoluble in water, soluble in fats,
DMSO,[1] heptane and hexane[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ionomycin is an

cations like magnesium and cadmium, but binds Ca2+ preferably.[1][2]

It has 14

chelate with calcium.[3]

It was extracted in 1978 and the complete structure was described in 1979.[2][3]

It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes.[3]

Ionomycin is often sold as a free acid, or as a Ca2+ salt. Both are insoluble in water, but soluble in fats and

DMSO. Because of their fat solubility, they bind to proteins like albumin, which may interfere with their use in studies involving blood.[1]

References

  1. ^
    PMID 21035685
    .
  2. ^
    ISSN 0002-7863
    .
  3. ^
    PMID 12027637
    .
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