Leslie B. Vosshall

Source: Wikipedia, the free encyclopedia.
Leslie B. Vosshall
The Rockefeller University
Doctoral advisorMichael W. Young
Other academic advisorsRichard Axel

Leslie Birgit Vosshall (born July 5, 1965) is an American

olfaction, particularly for the discovery and subsequent characterization of the insect olfactory receptor family, and the genetic basis of chemosensory behavior in mosquitoes.[2] She has also extended her research into the study of human olfaction, revealing parts of human genetic olfactory architecture, and finding variations in odorant receptors that determine individuals’ abilities to detect odors. [3]

Early life

Leslie Vosshall was born in Lausanne, Switzerland where she spent most of her early childhood. Vosshall moved to New Jersey when she was 8 years old. She spent summers from age 17 to 19 working in the laboratory of her uncle, Philip Dunham, with Gerald Weissmann at the Marine Biological Laboratory (MBL) in Woods Hole. Vosshall said this experience was "an incredible introduction to the practice of science."[4]

Education

Vosshall received her B.A. in biochemistry[5] from Columbia University in 1987 and her Ph.D. from Rockefeller University in 1993. She returned to Columbia for a postdoctoral fellowship in the laboratory of future Nobel laureate Richard Axel from 1993-1997. She then worked in the position of Associate Research Scientist in Dr. Axel's laboratory from 1997-2000. Vosshall was offered the position of Assistant Professor at The Rockefeller University in 2000, and was promoted to Associate Professor in 2006.[1] In April 2010, she was granted tenure and is currently the Robin Chemers Neustein Professor and Head of the Laboratory of Neurogenetics and Behavior.[6] She served as associate director of the Kavli Neural Systems Institute from 2015-2016 and was promoted to director in 2016.[1]

Research

Vosshall’s laboratory studies three organisms: fruit flies, mosquitoes and humans, to understand the genetic and molecular underpinnings, as well as behavioral mechanisms, involved in olfaction and feeding behavior.

dengue, and Zika,[9] found that it has a particular odor-detecting gene (AaegOr4) that is highly attuned to sulcatone, a compound predominant in human odor.[8][10] Research from Vosshall’s lab demonstrated that a chemical transferred from the male of the species during sex plays a key role in shaping the female’s sexual proclivities.[11][12] In addition, Vosshall and her associates discovered ORCO, a mosquito co-receptor responsible for preference for humans over non-human animals and sensitivity to insect-repellent DEET.[13][14]

Awards and honors

Key papers

Other selected publications

References

  1. ^ a b c d e "The Rockefeller University » Scientists & Research". www.rockefeller.edu. Retrieved 2017-03-10.
  2. PMID 32601194
    .
  3. ^ "Making the Paper: Leslie Vosshall and Hiroaki Matsunami". Nature. 449: xiii. 26 September 2007. Retrieved 15 July 2022.
  4. PMID 23193546
    .
  5. ^ "Leslie B. Vosshall". Our Scientists. Retrieved 2019-09-07.
  6. ^ Bonner, Joseph (2010-05-17). "The Rockefeller University: Leslie Vosshall promoted to professor". Retrieved 2017-10-24.
  7. ^ "Leslie B. Vosshall". Current Biology. 22 (28): PR782–R783. 25 September 2012. Retrieved 15 July 2022.
  8. ^ a b c "Researchers Find Gene that Makes Mosquitoes Prefer Humans over Animals". Entomology Today. Entomological Society of America. 13 November 2014. Retrieved 15 July 2022.
  9. ^ Lambert, Jonathon (25 April 2019). "How Do Mosquitoes Taste DEET? Hint: It's Not Their Mouthparts". Kuow.org. NPR. Retrieved 15 July 2022.
  10. ^
    PMID 25391959
    .
  11. ^ Fenz-Rockefeller, Katherine (9 January 2018). "Mosquito sex swap leaves females 'loyal'". Futurity. Retrieved 19 July 2022.
  12. ^ "Mosquito sex protein could stem disease spread". Sky News. 13 December 2017. Retrieved 15 July 2022.
  13. ^ Lambert, Jonathon (25 April 2019). "How Do Mosquitoes Taste DEET? Hint: It's Not Their Mouthparts". Kuow.org. NPR. Retrieved 15 July 2022.
  14. PMID 23719379
    .
  15. ^ "Leslie B. Vosshall". Arnold and Mabel Beckman Foundation. Retrieved 1 August 2018.
  16. ^ Burke, Adrienne (November 2007). "The New York Academy of Sciences - Blavatnik Awards for Young Scientists". Retrieved 2010-06-04.
  17. ^ Bonner, Joseph (2008-06-02). "The Rockefeller University: Two Rockefeller faculty become new HHMI investigators". Retrieved 2017-10-24.
  18. ^ "Howard Hughes Medical Institute - HHMI News: HHMI Selects 56 of the Nation's Top Scientists". 2008-05-27. Retrieved 2010-06-04.
  19. ^ "New York University - NYU School of Medicine Presents Three Biomedical Researchers 2010 Dart/NYU Biotechnology Awards for Role of Pure Science". 2010-03-22. Retrieved 2010-06-04.
  20. ^ "Leslie Vosshall and Jean-Laurent Casanova elected to the National Academy of Sciences". Retrieved 2017-10-24.
  21. ^ "National Academy of Medicine Elects 100 New Members". Oct 18, 2021. Retrieved 2021-10-20.
  22. PMID 24653035
    .
  23. .

External links