List of biosafety level 4 organisms
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Biosafety level 4 (BSL-4) organisms are dangerous or exotic agents which pose high risk of life-threatening disease, aerosol-transmitted lab infections, or related agents with unknown risk of transmission.[citation needed]
US federal biocontainment regulations
USDA animal safety list is located at 9 CFR Subchapter B.[4]
Not all
MERS-CoV are both non-select agents that are often handled in BSL-4 because they cause severe and fatal disease in humans. Newly characterized viruses closely related to select agents and/or BSL-4 viruses (for example newly discovered henipaviruses or ebolaviruses) are typically handled in BSL-4 even if they aren't yet known to be readily transmissible or cause severe disease.[citation needed
]
International BSL-4 regulations
Globally, there are no official agreements on what agents must be handled in BSL-4. However, select agents and toxins originating or ending in US BSL-4 labs must adhere to US select agent laws.[citation needed]
Select agents
HHS human threats: select agents and toxins
- Crimean-Congo hemorrhagic fever orthonairovirus
- Ebolavirus
- Lassa mammarenavirus
- Lujo mammarenavirus
- Marburg virus
- Reconstructed 1918 influenza virus
- Chapare mammarenavirus
- Guanarito mammarenavirus
- Argentinian mammarenavirus (formerly Junín virus)
- Machupo mammarenavirus
- Brazilian mammarenavirus(formerly Sabiá mammarenavirus)
- Far Eastern subtype Flavivirus
- Siberian subtype Flavivirus
- Kyasanur Forest disease virus
- Alkhurma virus
- Omsk hemorrhagic fever virus
- Variola major (Smallpox)
- Variola minor (Smallpox)
HHS human or animal threats: select agents and toxins
- Hendra henipavirus
- Nipah henipavirus
- Rift Valley fever phlebovirus
- Venezuelan equine encephalitis virus
Non-select agents
References
- ^ "Select agents and toxins list". Centers for Disease Control and Prevention / USDA Animal and Plant Health Inspection Service. Retrieved 18 August 2019.
- ^ "42 CFR § 73.3 - HHS select agents and toxins". LII / Legal Information Institute. Retrieved 21 August 2019.
- ^ "42 CFR § 73.4 - Overlap select agents and toxins". LII / Legal Information Institute. Retrieved 21 August 2019.
- ^ "9 CFR Subchapter B - COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES". LII / Legal Information Institute. Retrieved 21 August 2019.