List of intestinal epithelial differentiation genes

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Table of

intestinal epithelium[1]

The table listed below is a running comprehensive list of all intestinal differential genes that have been reported in the literature. The PMID is the pubmed identification number of the papers that support the summarized information in the table corresponding to each row.

Official Common Function/phenotype PMID
APC Conditional deletion promotes
beta-catenin
 15716339 [2]
ATOH1 Math1, HATH1 Commitment to secretory lineage 20691176[3] 17570220[4] 11739954 [5]
BLIMP1 PRDM1 Postnatal epithelial maturation; suckling/weaning transition 21878906 [6] 21670299 [7]
BMPR1A Involved in terminal differentiation of secretory cells 17678919 [8]
CBFA2T2 Mtgr1 Required for maintenance of secretory lineage 16227606 [9]
CDH1
 E-cadherin Required for maturation/localization of
goblet
cells		 21179475 [10]
CDX1 Cdx1 Induced expression promoted enterocyte differentiation in IEC6 cells 19059241 [11] 10579974 [12]
CDX2 Cdx2 Involves in
goblet
like cells		 21081128[13] 19386267[14] 8552090 [15]
CTNNB1
 Catenin, beta
crypt morphogenesis
with Tcf3 via c-Myc		 18948094[16] 17785439[17] 17681174 [18]
DLL1
 Functions as a
intestine. Required for the maintenance of stem and progenitors
 20170633[19] 21238454 [20]
DLL4
intestine. Required for the maintenance of stem and progenitors
 21238454 [20]
ELF3 ESE-1 Terminal differentiation of absorptive enterocytes 19801644 [21]
EPHB3 Localization of Paneth cells to crypt base 12408869 [22]
FGF7 KGF Regulate
epithelial growth and promote differentiation
 19326389 [23]
FGFR3
beta-catenin/Tcf4 dependent and independent pathway. Significant reduction in Paneth cell in knockout mice. Involved in crypt development and stem cell
expansion		 19407216 [24]
FOXA1 HNF3A Involved in
goblet cell differentiation and enteroendocrine differentiation
 19737569 [25]
FOXA2 HNF3B Involved in
goblet cell differentiation and enteroendocrine differentiation
 19737569 [25]
FZD5
 Required for Paneth cell maturation. Loss of Paneth cell genes after conditional deletion 15778706 [26]
GADD45GIP1 Crif1 Essential Elf3 coactivator in differentiation of absorptive enterocytes 19801644 [21]
GATA6 Regulates proximal-distal identity in the
intestines
 21262227 [27]
GATA4 Required for proximal intestinal identity 16940177 [28] 18812176 [29]
GFI1 Required for proper allocation of secretory lineage 16230531 [30]
HES1 Hes1 Commitment to absorptive lineage 10615124 [31]
HNF1A HNF1-α Regulates terminal
enterocytes
and secretory cells potentially by direct regulation of Atoh1		 20133952 [32] 20388655 [33]
HNF1B HNF1-β Regulates terminal
enterocytes
and secretory cells potentially by direct regulation of Atoh1		 20133952 [32] 20388655 [33]
IHH
 Colonocytes differentiation 14770182 [34]
KLF4 GKLF Promotes
colon
 21070761[35] 12015290 [36]
LGR4 GPR48 Promotes Paneth cell differentiation and crypt cell proliferation. Along with LGR5, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling 21508962 [37] 21909076 [38]
LGR5 GPR49 Premature
intestine. Intestinal stem cell
marker. Along with LGR4, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling		 19394326 [39] 21727895 [40]
MMP9 Negatively regulates terminal
colon
 17484881 [41]
MSI1
 Suppress paneth cell differentiation independent of Notch and Wnt signaling pathways 19214660 [42]
MYBL2 Regulates commitment of
stem cells to differentiate
 20857481;[43] 20133952 [44]
MYC Crypt loss upon conditional deletion in the adult 16954380 [45]
NEUROD1 BETA2 Differentiation of Ngn3 enteroendocrine cells into CCK and secretin cells 18022152;[46] 15044355 [47]
NEUROG3
 NGN3, ATOH5 Commitment to the enteroendocrine cell lineage 17706959;[48] 12456641 [49]
NKX2-2 Nkx2.2 Required for a subset of enteroendocrine cells differentiation 18022152 [46]
NOTCH1
 Regulates absorptive cells vs secretory cells 15959516;[50] 18274550 [51]
NOTCH2
 Regulates absorptive cells vs secretory cells 15959516;[50] 18274550 [51]
NOX1 Regulate
colon
 20351171 [52]
PAX6 Differentiation of GIP in enteroendocrine lineage 18022152;[46] 10478839 [53]
PDX1 IPF1 Overexpression causes differentiation of immature intestinal epithelia to enteroendocrine cells. Conditional deletion alters enterocyte and enteroendocrine gene expression 11408276;[54] 19808654 [55]
PPARD
 PPAR-δ/β Involves in Paneth cell maturation by modulating IHH expression 16890607 [56]
PTK6 BRK Promote cell cycle exit in Wnt independent pathway and promote enterocyte differentiation 16782882 [57]
RB1
 pRB Required for enterocyte terminal differentiation in small intestine 18981186 [58]
RBPJ CBF1 Conversion of
goblet
cells by conditional deletion		 15959515 [59]
REG4 Marker for
enteroendocrine cells
26287467 [60]
SOX9 Required for paneth cell differentiation 17698607;[61] 17681175 [62]
SPDEF PDEF Regulates terminal differentiation of
goblet cells and Paneth
cells		 19786015;[63] 19549527 [64]
STK11 LKB1 Required for normal
goblet and Paneth
cells		 19165340[65]
TGFBR2
 Tgf-βRII The critical downstream target of Elf3 for enterocyte differentiation 17408644 [66]
VAV Required for enterocyte
colon
 19139088 [67]

References

  1. PMID 21978911
    .
  2. PMID 15716339
    .
  3. PMID 20691176
    .
  4. PMID 17570220
    .
  5. S2CID 27540123
    .
  6. PMID 21878906
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  7. PMID 21670299
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  8. PMID 17678919
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  9. PMID 16227606
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  10. PMID 21179475
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  11. S2CID 21705505
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  12. PMID 10579974
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  13. PMID 21081128
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  14. PMID 19386267
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  15. PMID 8552090
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  16. PMID 18948094
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  17. PMID 17785439
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  18. PMID 17681174
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  19. PMID 20170633
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  20. ^
    PMID 21238454
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  21. ^
    PMID 19801644
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  22. PMID 12408869
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  23. S2CID 43767607
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  24. PMID 19407216
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  25. ^
    PMID 19737569
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  26. S2CID 15151752
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  27. PMID 21262227
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  28. PMID 16940177
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  29. PMID 18812176
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  30. PMID 16230531
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  31. S2CID 52872659
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  32. ^
    PMID 20133952
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  33. ^
    PMID 20388655
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  34. PMID 14770182
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  35. PMID 21070761
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  58. ^ Guo J, Longshore S, Nair R, Warner BW. Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine. J Biol Chem. 2009 Jan 2;284(1):134-40.
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