Macelignan

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Macelignan
Chemical structure of macelignan
Names
IUPAC name
(8S,8′R)-3-Methoxy-3′,4′-[methylenebis(oxy)]lignan-4-ol
Systematic IUPAC name
4-[(2S,3R)-4-(2H-1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol
Other names
Anwulignan
Identifiers
3D model (
JSmol
)
ChemSpider
UNII
  • InChI=1S/C20H24O4/c1-13(8-15-4-6-17(21)19(10-15)22-3)14(2)9-16-5-7-18-20(11-16)24-12-23-18/h4-7,10-11,13-14,21H,8-9,12H2,1-3H3/t13-,14+/m0/s1 ☒N
    Key: QDDILOVMGWUNGD-UONOGXRCSA-N ☒N
  • InChI=1/C20H24O4/c1-13(8-15-4-6-17(21)19(10-15)22-3)14(2)9-16-5-7-18-20(11-16)24-12-23-18/h4-7,10-11,13-14,21H,8-9,12H2,1-3H3/t13-,14+/m0/s1
    Key: QDDILOVMGWUNGD-UONOGXRCBH
  • C[C@H](CC1=CC2=C(C=C1)OCO2)[C@@H](C)CC3=CC(=C(C=C3)O)OC
Properties
C20H24O4
Molar mass 328.40 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Macelignan (Anwulignan) is a lignan. It can be found in Myristica fragrans, the nutmeg.

Medical research

One study has shown that macelignan may exert antimicrobial and anti

cariogenic activity against Streptococcus mutans, but this is not a currently used treatment.[1][2]

Macelignan may also act as an antidiabetic molecule via PPAR signaling[3] and upregulate adipocyte gene expression[4]

Macelignan may contain antioxidant and anti-inflammatory properties[5][4] and is marketed in breast enhancement creams for its anti-aging properties.[6]

References

  1. ^ Dental Caries and Medicinal Plants –An Overview. B. Parimala Devi and R. Ramasubramaniaraj, Journal of Pharmacy Research 2009, 2(11),1669-1675 "Dental Caries and Medicinal Plants –An Overview - B.Parimala Devi*, R.Ramasubramaniaraja - Journal of Pharmacy Research". Archived from the original on 2011-07-23. Retrieved 2011-08-27.
  2. ^ Therapeutic Potential of Peroxisome Proliferators–Activated Receptor-α/γ Dual Agonist With Alleviation of Endoplasmic Reticulum Stress for the Treatment of Diabetes http://diabetes.diabetesjournals.org/content/57/3/737.long
  3. ^
    S2CID 27489770
    .
  4. .
  5. ^ says, Tee O. "Best Breast Enlargement Creams Reviewed [UPDATED]". BreastEnlargement.name. Retrieved 2020-08-07.