Mackenzie Weygandt Mathis

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Mackenzie W. Mathis
Born
United States
NationalityAmerican
Alma materUniversity of Oregon, Harvard University
Known forDeepLabCut deep learning software for animal pose estimation, CEBRA
AwardsHarvard Rowland Fellow, ELLIS Society Scholar, FENS EJN 2022 Young Investigator Award, Eric Kandel Young Neuroscientist Prize 2023
Scientific career
FieldsNeuroscience, Machine Learning, Computer Vision
InstitutionsÉcole Polytechnique Fédérale de Lausanne, Rowland Institute at Harvard University
Thesis (2017)
Websitewww.mackenziemathislab.org

Mackenzie W. Mathis, is an American neuroscientist and principal investigator at the École Polytechnique Fédérale de Lausanne. Her lab investigates adaptive mechanisms in biological and artificial intelligence to inform adaptive AI systems and translational research.

Early life and education

Mathis conducted her undergraduate education at the

somatosensory cortex in forelimb motor adaptation in rodents.[7] Near the end of her PhD Mathis was awarded the Rowland Fellowship which provided five years of funding to start her own lab at Harvard's Rowland Institute in Cambridge, MA.[5] Prior to founding the Mathis Lab at Harvard, Mathis was also awarded the Women & the Brain (WATB) Fellowship for Advancement in Brain Science which provided her with the funding to work in Germany in the summer of 2017 under the mentorship of Professor Matthias Bethge at the University of Tübingen.[5] In her postdoctoral work, Mathis focused on pioneering deep learning tools for neural and behavioral analysis which served as a critical step towards her independent career.[8]

Career and research

In 2017, Mathis started her lab at the

Rowland Institute at Harvard University with a goal of reverse engineering neural circuits that drive adaptive motor behavior.[5] Through large-scale neural recordings and building novel robotic and machine learning tools, the Mathis Lab probes neural circuits and analyzes behavioral outputs to better understand how brain function relates to behavior.[9] Together with Alexander Mathis, Mathis developed DeepLabCut, a deep learning tool to track animal posture over time. This tool relies on transfer learning to optimize an ImageNet-pretrained foundation model and the feature detectors from DeeperCut,[10] to fine-tune on a desired new dataset after sufficient training.[11] Now the package includes many more networks, including their own DLCRNet with pose tracking and re-identification of animals.[12] Mathis has shown the versatility of this tool on many diverse datasets highlighting the robust design and potential for wide use in fields even beyond neuroscience.[13] Mathis is dedicated to the concept of open science[14] and as such, the novel deep learning tool she designed is open access such that researchers worldwide have access to the code in order to use this tool to analyze animal behaviors in an unbiased and precise way to inform a better understanding of how neural activity drives specific behaviors.[14][15][11] Her work has been featured in Nature,[16] Bloomberg Business Week,[17] and The Atlantic.[18]

As of August 2020, Mathis moved to the Swiss Federal Institute of Technology, working within the Brain Mind Institute, Center for Intelligent Systems & Neuro-X Institute as a tenure-track Professor.[19][20] The lab is hosted at the Campus Biotech in Geneva, Switzerland, where Mathis holds the Bertarelli Foundation Chair of Integrative Neuroscience.[21][20]

Awards and honors

  • 2023: Eric Kandel Young Neuroscientist Prize[22]
  • 2022: FENS EJN Young Investigator Prize[23]
  • 2020: Bertarelli Foundation Chair of Integrative Neuroscience
  • 2019 - 2023: CZI Essential Open Source Software for Science - grant for DeepLabCut[24]
  • 2019 - : ELLIS Society Fellow, Natural Intelligence[1]
  • 2018: Mind, Brain & Behavior Harvard University Faculty Award
  • 2018: eLife Travel Grant Award Winner[25]
  • 2017: NVIDIA GPU Grant[21]
  • 2017 - 2022: Rowland Fellowship[5]
  • 2017: Women & the Brain Fellowship for Advancement of Neuroscience[26]
  • 2013 - 2018: National Science Foundation Graduate Research Fellowship Life Sciences – Neuroscience[6]
  • 2013, ’14, ’16: Harvard University Certificate of Distinction in Teaching (MCB80, MCB145)[27]
  • 2014: Dr. Ernest Peralta Fund Award for Best Qualifying Exam proposal & defense, Harvard[19][28]
  • 2012 - 2013: Morris E. Zukerman Graduate Fellowship - awarded to top students in brain sciences at Harvard GSAS[19]

Publications

Mackenzie Weygandt Mathis publications indexed by Google Scholar

Personal life

Mathis is married to neuroscientist Dr. Alexander Mathis who is an assistant professor at the Swiss Federal Institute of Technology.[11][29] In her youth, she showed horses competitively in the US.[30]

References

  1. ^ a b c d "People". adaptive motor control lab. Retrieved March 25, 2020.
  2. ^ a b "Mackenzie Weygandt Mathis". scholar.harvard.edu. Retrieved March 25, 2020.
  3. PMID 23303937
    .
  4. ^ Boulting, G.L.*, Kiskinis, E.*, Croft, G.F.*, Amoroso, M.W.*, Oakley, D.H.*, Wainger, B.J., Williams, D.J., Kahler, D.J., Yamaki, M., Davidow, L.S., Rodolfa, C.T., Dimos, J.T., Mikkilineni, S., Macdermott, A.B., Woolf, C.J., Henderson, C.E., Wichterle, H., & Eggan, K.C. (2011). A functionally characterized test set of human induced pluripotent stem cells. Nature Biotechnology, 29, 279-286.
  5. ^ a b c d e f g h "MCO Graduate to Open Lab Through the Rowland Institute at Harvard". Harvard University - Department of Molecular & Cellular Biology. March 14, 2017. Retrieved March 25, 2020.
  6. ^ a b "FOUR MCB GRADUATE STUDENTS RECEIVE NSF FELLOWSHIPS IN 2013". Harvard University - Department of Molecular & Cellular Biology. April 11, 2013. Retrieved March 25, 2020.
  7. PMID 28334611
    .
  8. arXiv:1804.03142 [cs.CV
    ].
  9. ^ "Mackenzie Mathis". Harvard Brain Science Initiative. Retrieved March 25, 2020.
  10. arXiv:1605.03170 [cs.CV
    ].
  11. ^ a b c Yong, Ed (July 3, 2018). "A Game-Changing AI Tool for Tracking Animal Movements". The Atlantic. Retrieved March 25, 2020.
  12. doi:10.1038/s41592-022-01443-0
    .
  13. ^ "An open-source AI tool available to study movement across behaviors and species". Harvard Gazette. August 30, 2018. Retrieved March 25, 2020.
  14. ^ a b "Interview: A Deeper Cut Into Behavior With Mackenzie Mathis". Neuroscience from Technology Networks. Retrieved March 25, 2020.
  15. ^ "Apple, Google, and Facebook Are Raiding Animal Research Labs". Bloomberg.com. June 18, 2019. Retrieved March 25, 2020.
  16. PMID 31570871
    .
  17. ^ "Apple, Google, and Facebook Are Raiding Animal Research Labs". Bloomberg.com. June 18, 2019.
  18. ^ "A Game-Changing AI Tool for Tracking Animal Movements". The Atlantic. July 3, 2018.
  19. ^ a b c "adaptive motor control lab". adaptive motor control lab. Retrieved March 25, 2020.
  20. ^ a b Evangelista, Sandy (September 27, 2019). "Nominations of EPFL professors". {{cite journal}}: Cite journal requires |journal= (help)
  21. ^ a b "News". adaptive motor control lab. Retrieved March 25, 2020.
  22. ^ "Recipients of the Eric Kandel Young Neuroscientists Prize 2023 announced". www.fens.org. July 29, 2023. Retrieved September 26, 2023.
  23. ^ Lion, Niels (August 23, 2021). "FENS 2022 Young Investigator Prize". Retrieved August 23, 2021.
  24. ^ "CZI – Essential Open Source Software for Science". Chan Zuckerberg Initiative. Retrieved March 25, 2020.
  25. ^ "Early-career researcher travel grants 2018: First seven authors selected". eLife. April 3, 2018. Retrieved March 25, 2020.
  26. ^ "BETHGE LAB · Funding". bethgelab.org. Retrieved March 25, 2020.
  27. ^ "awards Archives". Harvard University - Department of Molecular & Cellular Biology. Retrieved March 25, 2020.
  28. ^ "Ernest Peralta Fund Award Archives". Harvard University - Department of Molecular & Cellular Biology. Retrieved March 25, 2020.
  29. ^ "Alexander Mathis | About". www.people.fas.harvard.edu. Retrieved March 25, 2020.
  30. ISSN 1548-7105
    .
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