N100

In

The N100 is preattentive and involved in perception because its amplitude is strongly dependent upon such things as the rise time of the onset of a sound,^[10] its loudness,^[11] interstimulus interval with other sounds,^[12] and the comparative frequency of a sound as its amplitude increases in proportion to how much a sound differs in frequency from a preceding one.^[13] Neuromagnetic research has linked it further to perception by finding that the auditory cortex has a tonotopic organization to N100.^[14] However, it also shows a link to a person's arousal^[15] and selective attention.^[16] N100 is decreased when a person controls the creation of auditory stimuli,^[17] such as their own voice.^[18]

Types

There are three subtypes of adult auditory N100.^[9]

• N100b or vertex N100, peaking at 100 ms.
• T-complex N100a, largest at temporal
  electrodes
  at 75 ms
• T-complex N100c, follows N100a and peaks at about 130 ms. The two T-complex N100 evoked potentials are created by auditory association cortices in the superior temporal gyri.

Elicitation

The N100 is often known as the "auditory N100" because it is elicited by perception of auditory stimuli. Specifically, it has been found to be sensitive to things such as the predictability of an auditory stimulus, and special features of speech sounds such as voice onset time.

During sleep

It occurs during both

The N100 depends upon unpredictability of stimulus: it is weaker when stimuli are repetitive, and stronger when they are random. When subjects are allowed to control stimuli, using a switch, the N100 may decrease.[17] This effect has been linked to intelligence, as the N100 attenuation for self-controlled stimuli occurs the most strongly (i.e., the N100 shrinks the most) in individuals who are also evaluated as having high intelligence. Indeed, researchers have found that in those with Down syndrome "the amplitude of the self-evoked response actually exceeded that of the machine-evoked potential".^[17] Being warned about an upcoming stimulus also reduces its N100.^[22]

The amplitude of N100 shows refractoriness upon repetition of a stimulus; in other words, it decreases at first upon repeated presentations of the stimulus, but after a short period of silence it returns to its previous level.^[9] Paradoxically, at short repetition the second N100 is enhanced both for sound^[23] and somatosensory stimuli.^[6]

With paired clicks, the second N100 is reduced due to sensory gating.^[24]

Voice onset time

The difference between many consonants is their voice onset time (VOT), the interval between consonant release (onset) and the start of rhythmic vocal cord vibrations in the vowel. The voiced stop consonants /b/, /d/ and /g/ have a short VOT, and unvoiced stop consonants /p/, /t/ and /k/ long VOTs. The N100 plays a role in recognizing the difference and categorizing these sounds: speech stimuli with a short 0 to +30 ms voice onset time evoke a single N100 response but those with a longer (+30 ms and longer) evoked two N100 peaks and these are linked to the consonant release and vocal cord vibration onset.^[25][26]

Top-down influences

Traditionally, 50 to 150 ms evoked potentials were considered too short to be influenced by top-down influences from the

Another top-down influence upon N100 has been suggested to be efference copies from a person's intended movements so that the stimulation that results from them are not processed.^[30] A person's own voice produces a reduced N100^[18] as does the effect of a self-initiated compared to externally created perturbation upon balance.^[31]

Development in children

The N100 is a slow-developing evoked potential. From one to four years of age, a positive evoked potential, P100, is the predominant peak.

The various types of N100 mature at different times. Their maturation also varies with the side of the brain: N100a in the left hemisphere is mature before three years of age but this does not happen in the right hemisphere until seven or eight years of age.[33]

Clinical use

The N100 may be used to test for abnormalities in the auditory system where verbal or behavioral responses cannot be used,

High density mapping of the location of the generators of M100 is being researched as a means of presurgical neuromapping needed for neurosurgery.^[40]

Many cognitive or other mental impairments are associated with changes in the N100 response, including the following:

• There is some evidence that the N100 is affected in those with dyslexia and specific language impairment.^[41]
• The sensory gating effect upon N100 with paired clicks is reduced in those with schizophrenia.^[24]
• In individuals with tinnitus, those with smaller N100 are less distressed than those with larger amplitudes.^[42]
• Migraine is associated with an increase rather than decrease in N100 amplitude with repetition of the high-intensity stimulation.^[43]
• Headache sufferers also have more reactive N100 to somatosensory input than nonsufferers^[44]

The N100 is 10 to 20% larger than normal when the auditory stimulus is synchronized with the diastolic phase of the cardiac blood pressure pulse.^[45]

Relationship to mismatch negativity

The Mismatch negativity (MMN) is an evoked potential that occurs at roughly the same time as N100 in response to rare auditory events. It differs from the N100 in that:

• They are generated in different locations.^[46]
• The MMN occurs too late to be an N100.^[47]
• The MMN, unlike N100, may be elicited by stimulus omissions (i.e., not hearing a stimulus when you expect to hear one).^[48]

Though this suggests that they are separate processes, arguments have been made that this is not necessarily so and that they are created by the "relative activation of multiple cortical areas contributing to both of these 'components'".^[49]

History

Pauline A. Davis at Harvard University first recorded the wave peak now identified with N100.^[50] The present use of the N1 to describe this peak originates in 1966^[51] and N100 later in the mid 1970s.^[52] The origin of the wave for a long time was unknown and only linked to the auditory cortex in 1970.^[9][53]

Due to

References