NOD2
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| Location (UCSC) | Chr 16: 50.69 – 50.73 Mb | Chr 8: 89.37 – 89.42 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a
peptidoglycans) and stimulates an immune reaction.[7]
NOD2 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.[8]
Structure
The
Function
This gene is a member of the
leukocytes. It plays a role in the immune response by recognizing the bacterial molecules which possess the muramyl dipeptide (MDP) moiety and activating the NF-κB protein.[11]
Clinical significance
Mutations in this gene have been associated with Crohn's disease,[9] Blau syndrome, severe pulmonary sarcoidosis[12] and Graft-versus-host disease.[13]
The NOD2 gene is linked to inflammatory diseases such as Inflammatory bowel disease/Crohn's disease, Yao Syndrome and Blau syndrome.[14][15]
Interactions
NOD2 has been shown to interact with NLRC4.[16][17]
NOD2 has also been shown to bind to
MAVS in response to ssRNA or viral RNA treatment and activate the IFN response. This is the first report of NOD2 acting as a pattern-recognition receptor for viruses.[18]
See also
- Mifamurtide, a NOD2 activator for the treatment of osteosarcoma
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167207 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055994 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7809109.
- S2CID 4311407.
- PMID 24032031.
- S2CID 20217610.
- ^ PMID 22319155.
- PMID 11087742.
- ^ "Entrez Gene: NOD2 nucleotide-binding oligomerization domain containing 2".
- PMID 19679608.
- S2CID 206850232.
- PMID 17131470.
- S2CID 23739992.
- PMID 15107016.
- PMID 11472070.
- PMID 19701189.
Further reading
- Punchard NA (Oct 2001). "Overview: Nod2, cause of, or contributor to, Crohn's disease". Current Opinion in Investigational Drugs. 2 (10): 1378–81. PMID 11890351.
- Satsangi J, Morecroft J, Shah NB, Nimmo E (Feb 2003). "Genetics of inflammatory bowel disease: scientific and clinical implications". Best Practice & Research. Clinical Gastroenterology. 17 (1): 3–18. PMID 12617879.
- Rosenbaum JT, Planck SR, Davey MP, Iwanaga Y, Kurz DE, Martin TM (Oct 2003). "With a mere nod, uveitis enters a new era". American Journal of Ophthalmology. 136 (4): 729–32. PMID 14516815.
- Kurokawa T, Kikuchi T, Ohta K, Imai H, Yoshimura N (Oct 2003). "Ocular manifestations in Blau syndrome associated with a CARD15/Nod2 mutation". Ophthalmology. 110 (10): 2040–4. PMID 14522785.
- Girardin SE, Hugot JP, Sansonetti PJ (Dec 2003). "Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing". Trends in Immunology. 24 (12): 652–8. PMID 14644139.
- Newman B, Siminovitch K (Dec 2003). "Inflammatory bowel disease: Crohn's disease and the success of NODern genetics". Clinical and Investigative Medicine. 26 (6): 303–14. PMID 14690304.
- Oostenbrug LE, van Dullemen HM, te Meerman GJ, Jansen PL (2003). "IBD and genetics: new developments". Scandinavian Journal of Gastroenterology. Supplement. 38 (239): 63–8. PMID 14743885.)
{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link - Kambe N, Nishikomori R, Kanazawa N (Aug 2005). "The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disorders". Journal of Dermatological Science. 39 (2): 71–80. PMID 15927452.
- Newman B, Siminovitch KA (Jul 2005). "Recent advances in the genetics of inflammatory bowel disease". Current Opinion in Gastroenterology. 21 (4): 401–7. PMID 15930978.
- Martinon F, Tschopp J (Aug 2005). "NLRs join TLRs as innate sensors of pathogens". Trends in Immunology. 26 (8): 447–54. PMID 15967716.
- Strober W, Murray PJ, Kitani A, Watanabe T (Jan 2006). "Signalling pathways and molecular interactions of NOD1 and NOD2". Nature Reviews. Immunology. 6 (1): 9–20. S2CID 33505741.
- Cavanaugh J (Jun 2006). "NOD2: ethnic and geographic differences". World Journal of Gastroenterology. 12 (23): 3673–7. PMID 16773683.
- Hugot JP (Aug 2006). "CARD15/NOD2 mutations in Crohn's disease". Annals of the New York Academy of Sciences. 1072 (1): 9–18. S2CID 24150549.
- Vignal C, Singer E, Peyrin-Biroulet L, Desreumaux P, Chamaillard M (Apr 2007). "How NOD2 mutations predispose to Crohn's disease?". Microbes and Infection / Institut Pasteur. 9 (5): 658–63. PMID 17379562.
- Quaglietta L, te Velde A, Staiano A, Troncone R, Hommes DW (May 2007). "Functional consequences of NOD2/CARD15 mutations in Crohn disease". Journal of Pediatric Gastroenterology and Nutrition. 44 (5): 529–39. S2CID 37476303.
- van der Linde K, Boor PP, Houwing-Duistermaat JJ, Crusius BJ, Wilson PJ, Kuipers EJ, de Rooij FW (Jun 2007). "CARD15 mutations in Dutch familial and sporadic inflammatory bowel disease and an overview of European studies". European Journal of Gastroenterology & Hepatology. 19 (6): 449–59. S2CID 17766170.