Nevus lipomatosus superficialis
| Nevus lipomatosus superficialis | |
|---|---|
| Other names | Nevus lipomatosis of Hoffman and Zurhelle |
 | |
| Specialty | Dermatology |
Nevus lipomatosus superficialis (NLS or NLCS, also known as nevus lipomatosis of Hoffman and Zurhelle
A pedunculated lipofibroma is a solitary variant of nevus lipomatosus superficialis. It usually appears in adult life, and usually on the axilla, knee, ear, arm, scalp and the lower trunk.[3]
In both multiple and solitary variants, the
Signs and symptoms
Clinically, there are two variations. The most prevalent variety, known as the classical type, is characterized by a number of flesh-colored or yellowish sessile lesions that have a propensity to combine into smooth or cerebriform plaques that are distributed linearly, zosteriformly, or segmentally. Lessons tend to focus on the lower trunk, particularly the gluteal, sacrum, and lumbar regions as well as the
The second clinical pattern of NLCS is a solitary papule or nodule that typically appears later in life. It mimics a skin tag in appearance and is flesh-colored and domed. The solitary form, which has been reported on the arms, knees, ears, axillae, nose, calves, clitoris, and scalp, has no known specific distribution.[5][6][7]
The lesions are asymptomatic in both forms.[8] In rare cases, ulceration happens, particularly following ischemia or external damage.[9] Moreover, coexisting comedo-like changes, leukodermic patches, café-au-lait macules, and overlaying hypertrichosis are possible.[10][11]
Causes
Although the pathophysiology of NLCS is unknown, ectopic adipocytes may arise from pericytes, similar to embryonic lipogenesis, or from precursor cells from the dermal arteries.[12][13]
Diagnosis
The histology of NLCS typically demonstrates the proliferation of ectopic mature
Clinically, NLCS needs to be distinguished from focal dermal hypoplasia (Goltz syndrome), neurofibroma, lymphangioma, hemangioma, sebaceous nevus, and connective tissue nevus.[9][11]
Treatment
Given the rarity of malignant degeneration and systemic problems, treatment is only recommended for cosmetic reasons.[10] The best course of treatment is surgical excision because recurrence lesions are uncommon.[11]
See also
- Skin lesion
- List of cutaneous conditions
References
Further reading
- Castro Zayas, Paola M.; Aboukheir Aboukheir, Aihab; Martínez Bernal, Atenas; Ortíz Justiniano, Victor (2021). "Nevus Lipomatosus Cutaneous Superficialis". Journal of Pediatric Surgery Case Reports. 74. Elsevier BV: 102036. ISSN 2213-5766.
- Takegawa, Masayasu; Kakudo, Natsuko; Morimoto, Naoki; Hihara, Masakatsu; Masuoka, Hiromu; Kusumoto, Kenji (2018). "Giant Nevus Lipomatosus Cutaneous Superficialis on the Buttock". Plastic and Reconstructive Surgery — Global Open. 6 (11): e1918. PMID 30881777.