Olke C. Uhlenbeck
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O. C. Uhlenbeck | |
|---|---|
| Citizenship | American |
| Alma mater | University of Michigan Harvard University |
| Known for | RNA synthesis from synthetic templates, RNA-protein interactions, RNA Biochemistry |
| Spouse | |
| Scientific career | |
| Fields | |
| Doctoral advisor | Paul Doty |
Olke C. Uhlenbeck is a Professor Emeritus of Biochemistry at the University of Colorado Boulder[1] and at Northwestern University.[2][3]
His research group has led to many breakthroughs in
Education
He completed his undergraduate degree at the
Research
He is known for his studies of RNA biochemistry. Some[who?] have called him the "Father of RNA".[8]
Uhlenbeck was first published in 1968 at
In the 1970s, he began his work on RNA. As a
In 1987, his research found that
He has also researched RNA
Uhlenbeck studied how amino acids that are esterified interact with tRNA differently.[13]
Uhlenbeck Lab
| This article contains wording that unnoteworthy facts. (June 2021) ) |
Uhlenbeck runs the Uhlenbeck lab at Northwestern University after having moved it from the University of Colorado Boulder. Their current research focuses on the recognition and activity of modified tRNA. One of their major focuses is the development of an aminoacyl tRNA synthetase, which allows the researchers to conduct their experiment when there is excess enzyme in the environment.[2]
Notable contributions include:
- Walker, G. C.; Uhlenbeck, OC; Bedows, E; Gumport, RI (1975). "T4-Induced RNA Ligase Joins Single-Stranded Oligoribonucleotides". Proceedings of the National Academy of Sciences. 72 (1): 122–6. PMID 1090929.
- England, Thomas E.; Uhlenbeck, Olke C. (1978). "3′-Terminal labelling of RNA with T4 RNA ligase". Nature. 275 (5680): 560–1. S2CID 4153471.
- Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. PMID 3684574.
- Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. PMID 3684574.
- Hertel, Klemens J.; Herschlag, Daniel; Uhlenbeck, Olke C. (1994). "A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction". Biochemistry. 33 (11): 3374–85. PMID 8136375.
- Johansson, H. E. (1998). "A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein". Proceedings of the National Academy of Sciences. 95 (16): 9244–9. PMID 9689065.
- Sampson, J. R. (1988). "Biochemical and Physical Characterization of an Unmodified Yeast Phenylalanine Transfer RNA Transcribed in vitro". Proceedings of the National Academy of Sciences. 85 (4): 1033–7. PMID 3277187.
- Sampson, JR; Direnzo, A.; Behlen, L.; Uhlenbeck, O. (1989). "Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase". Science. 243 (4896): 1363–6. PMID 2646717.
- Lariviere, F. J.; Wolfson, AD; Uhlenbeck, OC (2001). "Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation". Science. 294 (5540): 165–8. S2CID 26192336.
Recognition
In 1993, Uhlenbeck was inducted into the National Academy of Sciences for his work in RNA biochemistry.[14]
John Milligan and his wife created the "Olke C. Uhlenbeck Endowed Graduate Fund" which funds the tuition of first-year graduate students pursuing their doctorate degrees at the University of Colorado, Boulder. It was named after Uhlenbeck because of the impact he made on the biochemistry department at Colorado.[6]
In 2013, Uhlenbeck was awarded the Fritz Lipmann Lectureship, which is given to someone who has made substantial and influential advancements in biochemistry. He was awarded this due to his research on RNA biochemistry. The award includes a $3,000 prize and funding to present at the Experimental Biology conference in Boston.[8]
Personal life
Uhlenbeck's father was theoretical physicist George Uhlenbeck. He was married to Karen Uhlenbeck between 1965 and 1976.[15] John F. Milligan, a colleague of Uhlenbeck's, said that he appreciated the conversations they had as he developed into a scientist. He also said that Uhlenbeck taught him how to be a leader by showing him what it meant to be engaged in research and how to be intellectually curious. This was said by Milligan after his time working in the Uhlenbeck lab at the CU Boulder.[6]
See also
References
- ^ "Faculty". 21 August 2018.
- ^ a b "Northwestern University Department of Molecular Biosciences The Uhlenbeck Lab Research". groups.molbiosci.northwestern.edu. Retrieved 2020-04-18.
- ^ "Olke C. Uhlenbeck". Northwestern University. Retrieved 2021-05-06.
- PMID 3684574.
- ^ "An Imperfect Account of the Founding of the RNA Society". The RNA society.
- ^ a b c d "$1 million gift to BioFrontiers Institute to aid graduate students". CU Boulder Today. 2016-07-29. Retrieved 2020-04-18.
- S2CID 91936.
- ^ a b "Renowned researcher Uhlenbeck wins Lipmann lectureship for work on RNA biochemistry". www.asbmb.org. Retrieved 2020-04-18.
- ISBN 978-0-12-395638-5, retrieved 2020-04-18
- S2CID 4283534.
- PMID 3684574.
- PMID 3297131.
- PMID 30059836.
- ^ "Olke Uhlenbeck". www.nasonline.org. Retrieved 2020-04-18.
- Celebratio Mathematica.