Open-label trial

Source: Wikipedia, the free encyclopedia.

An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants.[1] In particular, both the researchers and participants know which treatment is being administered.[1] This contrasts with a double-blinded trial, where information is withheld both from the researchers and the participants to reduce bias.[2][3]

Open-label trials may be appropriate for comparing two similar treatments to determine which is most effective, such as a comparison of different

symptoms of some disorders when a placebo is given.[5]

An open-label trial may still be randomized. Open-label trials may also be uncontrolled (without a placebo group), with all participants receiving the same treatment.[4]

References

  1. ^ a b "Open label study". National Cancer Institute, US National Institutes of Health. 2020. Retrieved 20 November 2020.
  2. ^ "Double-blind (trial)". Merriam-Webster Medical Dictionary. 2020. Retrieved 20 November 2020.
  3. ^ "Double-blind study". HIV.gov, Office of AIDS Research, US National Institutes of Health. 2020. Retrieved 20 November 2020.
  4. ^
    PMID 21920015
    .
  5. PMID 28545508
    .
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