PGAM2
| PGAM2 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 7: 44.06 – 44.07 Mb | Chr 11: 5.75 – 5.75 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Phosphoglycerate mutase 2 (PGAM2), also known as muscle-specific phosphoglycerate mutase (PGAM-M), is a phosphoglycerate mutase that, in humans, is encoded by the PGAM2 gene on chromosome 7.[5][6]
Structure
PGAM2 is one of two genes in humans encoding a PGAM subunit, the other being
Gene
The PGAM2 gene is composed of three
Protein
The isozyme encoded by PGAM2 spans 253
One key residue in the active site of PGAM2, lysine 100 (K100), is highly conserved across bacteria, to yeast, plant, and mammals, indicating its evolutionary importance. K100 directly contacts the substrate (3-PGA) and intermediate (2,3-PGA); however, the acetylation of this residue under normal cellular conditions neutralizes its positive charge and interferes with this binding.[9]
Mechanism
PGAM2 catalyzes the 3-PG-to-2-PG isomerization via a 2-step process:
- a phosphate group from the phosphohistidine in the active site is transferred to the C-2 carbon of 3-PGA to form 2,3-bisphosglycerate (2,3-PGA), and then
- the phosphate group linked to the C-3 carbon of 2,3-PG is transferred to the catalytic histidine to form 2-PGA and regenerate the phosphohistidine.[9]
Function
PGAM2 is one of two PGAM subunits found in humans and is predominantly expressed in adult
Clinical significance
PGAM activity is upregulated in
In a patient with intolerance for strenuous exercise and persistent pigmenturia, PGAM2 activity was found to be decreased relative to other glycolytic enzymes.
Interactions
PGAM2 is known to
- SIRT2.[9]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".
See also
- Phosphoglycerate mutase
- PGAM1
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164708 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020475 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: PGAM2, phosphoglycerate mutase 2 (muscle)".
- ^ "UniProtKB: P15259".
- ^ PMID 2145198.
- ^ PMID 2549058.
- ^ PMID 24786789.
- ^ PMID 8447317.
- PMID 6262916.
- ^ S2CID 33450920.
This article incorporates text from the United States National Library of Medicine ([1]), which is in the public domain.