Polysorbate 20
Names | |
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IUPAC name
Polyoxyethylene (20) sorbitan monolaurate
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Other names
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Identifiers | |
ChemSpider |
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ECHA InfoCard
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100.105.528 |
E number | E432 (thickeners, ...) |
RTECS number
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C58H114O26 | |
Molar mass | 1226 g/mol |
Appearance | Clear, yellow to yellow-green viscous liquid. |
Density | 1.1 g/mL (approximate) |
Boiling point | > 100 °C (212 °F; 373 K) |
Surface tension: | |
8.04×10−5 M at 21 °C[1] | |
16.7[1] | |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Irritant |
NFPA 704 (fire diamond) | |
Flash point | 110 °C (230 °F; 383 K) |
Safety data sheet (SDS) | External MSDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Polysorbate 20 (common commercial brand names include Kolliphor PS 20,
Food applications
Polysorbate 20 is used as a
The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.[4]
Biotechnical applications
In biological techniques and sciences, polysorbate 20 has a broad range of applications. For example, it is used:
- as a washing agent in phosphate buffered salineat dilutions of 0.05% to 0.5% v/v. These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.
- to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
- to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosisexposure
- as a solubilizing agent of membrane proteins
- for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.
Pharmaceutical applications
Polysorbate 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
Industrial and domestic applications
Polysorbate 20 is used in many brands of baby wipes.
Polysorbate 20 is used by
Polysorbate 20 is also used as wetting agent in rubber balers in the elastomer industry.
Polysorbate 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.[5]
See also
References
- ^ .
- ^ "Polysorbates and Sorbitan Esters for Pharmaceutical Applications". BASF Pharma. Retrieved 2022-06-10.
- PMID 11114018.
- ^ Joint FAO/WHO Expert Committee on Food Additives (1974). "Toxicological evaluation of some food additives including anticaking agents, antimicrobials, antioxidants, emulsifiers and thickening agents". WHO Food Additives Series No. 5. World Health Organization.
- ^ Q. Maqbool, C. Singh, A. Paul and A. Srivastava J. Mat. Chem. C, 2015, 3, 1610