Protoporphyrinogen IX

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Protoporphyrinogen IX
Identifiers
MeSH protoporphyrinogen
Properties
C34H38N4O4
Molar mass 566.7 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Protoporphyrinogen IX is an organic chemical compound which is produced along the synthesis of porphyrins, a class of critical biochemicals that include hemoglobin and chlorophyll. It is a direct precursor of protoporphyrin IX.

The compound is a

oxidized to a porphine core in later stages of the heme synthesis. Like most porphyrinogens, it is colorless.[citation needed
]

Biosynthesis

The compound is synthesized in most organisms from

coproporphyrinogen oxidase
:

Proptoporphyrinogen IX synthesis from coproporphyrinogen III

The process entails conversion of two of four propionic acid groups to vinyl groups. In coproporphyrinogen III, the substituents on the pyrrole rings have the arrangement MP-MP-MP-PM, where M and P are methyl and propionic acid, respectively. In protoporphyrinogen IX, the sequence becomes MV-MV-MP-PM, where V is vinyl.

By the action of protoporphyrinogen oxidase, protoporphyrinogen IX is later converted into protoporphyrin IX, the first colored tetrapyrrole in the biosynthesis of hemes.[1]

References

  1. ISBN 978-0470048672
    .

See also


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