Rosetta Genomics
This article needs to be updated.(August 2022) |
Company type | Jersey City, U.S. |
---|---|
Key people | Ken Berlin (President and CEO) Dr. Isaac Bentwich ( Founder) |
Products | microRNA-based diagnostic tests and therapeutics |
Number of employees | 70 (as of 2008) |
Website | www.rosettagenomics.com |
Rosetta Genomics Ltd. was a molecular
In April 2008, Nature Biotechnology published a study by Rosetta Genomics’ scientists whose findings demonstrate microRNAs' significant potential to act as effective biomarkers that may be applied in a diagnostic test designed to identify the primary tumor site in patients CUP.[5] In addition to its diagnostic programs, Rosetta Genomics is collaborating with Isis Pharmaceuticals to develop a microRNA-based therapy for Hepatocellular carcinoma (HCC), a form of liver cancer.[6]
Intellectual property
Rosetta Genomics has developed a microRNA discovery process.[7]
Platform technologies
Rosetta Genomics has developed several proprietary technologies that enable the Company to work with microRNAs. At the basis of these technologies are proprietary microRNA extraction protocols that include sensitive extraction of microRNAs from most body fluids, including serum, urine, saliva, with virtually no microRNA lost in the extraction process.[8] The company has also developed a microRNA extraction protocol from Formalin Fixed Paraffin Embedded, or FFPE, samples. This allows extraction of microRNAs from samples preserved at room temperature.[9]
Once microRNAs are extracted, Rosetta Genomics’ technology is capable of detecting and quantifying the microRNAs using two custom designed platform technologies which utilize Quantitative Real Time PCR (or qRT-PCR) and microarrays.[10]
The Company’s proprietary microarray platform covers approximately 850 human microRNAs, including approximately 180 microRNAs[11] which are Rosetta Genomics’ proprietary microRNAs. The array’s high specificity allows discriminating homologous family members.
Licenses and collaborations
In January 2008, Rosetta Genomics announced a collaboration agreement with the
In May 2007, Rosetta Genomics announced
In February 2006, Isis Pharmaceuticals Inc. and Rosetta Genomics said they will collaborate to develop
History
Rosetta Genomics was founded by Isaac Bentwich in 2000
In 2016, the company was ranked #27 on the
In 2017, the company was sold for $10 million to private US company Genoptix.[21]
On 31 May 2018, it was announced that Rosetta Genomics filed for Chapter 7 bankruptcy.[22]
References
- ^ Chambers, Heather. "Isis, Alnylam Pair To Seek Disease-Fighting Drugs." San Diego Business Journal, September 17, 2007.
- ^ a b "Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinical Laboratory Evaluation Program," Forbes.com, April 3, 2008
- ^ a b "Rosetta Genomics Ltd. Completes Prevalidation Phase for First Diagnostic Production." Reuters, October 30, 2007.
- ^ a b Boggs, Jennifer. "Rosetta Genomics' IPO Raising $26.3M For MicroRNA Work."BioWorld Today, February 28, 2007.
- S2CID 4788303.
- ^ "Antisense Oligonucleotide, Heptacellular carcinoma, Isis/Rosetta Genomics Isis, Rosetta Genomics Licensing Agreement." R&D Focus Drug News, March 6, 2006.
- ^
Bentwich I, Avniel A, Karov Y, et al. (July 2005). "Identification of hundreds of conserved and nonconserved human microRNAs". Nat. Genet. 37 (7): 766–70. S2CID 7746954.
- ^ "Other News To Note," Bioworld Today, April 3, 2007.
- ^ "Henry Ford Hospital and Rosetta Genomics To Develop MicroRNA-based Diagnostics For Brain Cancer," Company Reports, January 14, 2008.
- ^ "Nanogen, Inc. Licenses MGB Probe Technology To Rosetta Genomics, Ltd.," Reuters Significant Developments, December 11, 2007.
- ^ "Rosetta and Rockefeller Enter MicroRNA Agreement," Datamonitor News and Comment, June 16, 2006.
- ^ "Business Diary: Acquisitions," Crain's Detroit Business, February 25, 2008.
- ^ "Rosetta Genomics Licenses Roche PCR Technology". 'FDAnews Device Daily Bulletin. 9 January 2008.
- ^ Everitt, Jay. "Rosetta Genomics, Ltd--ROSG: To Work In Collaboration With NYU Medical Center," Knobias, September 7, 2007.
- ^ "Rosetta Genomics Ltd. Signs Agreement With Columbia University Medical center," Reuters, May 21, 2007.
- ^ "Isis, Rosetta Join On Cancer Treatment," Associated Press, February 22, 2006.
- ^ Herper, Matthew; Langreth, Robert (12 December 2005). "Treasures In The Trash". Forbes.[dead link]
- ^ "Rosetta Genomics Company Description".
- ^ "Alnylam Pharma Shares Rise On Cantor Fitgerald's microRNA Technology Outlook," Associated Press, September 11, 2007.
- ^ "2016 Winners by rank" (PDF). Deloitte. Archived from the original (PDF) on 21 November 2016. Retrieved 14 October 2017.
- ^ "Rosetta Genomics sold for $10m". Globes (in Hebrew). 2017-12-17. Retrieved 2020-07-20.
- ^ Rosetta Genomics Files for Chapter 7 Bankruptcy (subscription required)