SAM-V riboswitch
| SAM-V | |
|---|---|
 Conserved secondary structure of the SAM-V riboswitch. | |
| Identifiers | |
| Symbol | SAM-V |
| Rfam | RF01826 |
| Other data | |
| RNA type | Cis-reg; Riboswitch; |
| Domain(s) | Marine metagenome |
| PDB structures | PDBe |
SAM-V riboswitch is the fifth known
secondary structure as the binding site of SAM-II riboswitch, but bioinformatics scans cluster the two aptamers independently. These similar binding pockets suggest that the two riboswitches have undergone convergent evolution.[2]
SAM-binding was confirmed using
marine bacteria.[2]
The crystal structure of the riboswitch has been solved (PDB 6FZ0). It contains a pseudoknot.[3]
See also
References
Further reading
- Kazanov MD, Vitreschak AG, Gelfand MS (2007). "Abundance and functional diversity of riboswitches in microbial communities". BMC Genomics. 8: 347. PMID 17908319.
- Zhu Y, Pulukkunat DK, Li Y (2007). "Deciphering RNA structural diversity and systematic phylogeny from microbial metagenomes". Nucleic Acids Res. 35 (7): 2283–2294. PMID 17389640.
- Winkler WC, Breaker RR (2005). "Regulation of bacterial gene expression by riboswitches". Annu. Rev. Microbiol. 59: 487–517. PMID 16153177.
- Mandal M, Lee M, Barrick JE, et al. (October 2004). "A glycine-dependent riboswitch that uses cooperative binding to control gene expression". Science. 306 (5694): 275–279. S2CID 14311773.
- Yooseph S, Sutton G, Rusch DB, et al. (March 2007). "The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families". PLOS Biol. 5 (3): e16. PMID 17355171.