Salmonid herpesvirus 3

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Salmonid herpesvirus 3
Virus classification Edit this classification
(unranked): Virus
Realm: Duplodnaviria
Kingdom:
Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Alloherpesviridae
Genus:
Salmonivirus
Species:
Salmonid herpesvirus 3
Synonyms
  • SalHV-3
  • Epizootic epitheliotrophic disease virus (EEDV)

Salmonid herpesvirus 3 (SalHV-3) is a species of virus in the genus

Salmonivirus, family Alloherpesviridae, and order Herpesvirales.[1]

The virus has been referred to as epizootic epitheliotrophic disease virus (EEDV) after the disease caused by the virus was first referred to as epizootic epitheliotrophic disease (EED) in 1989.[2]

Salmonid herpesvirus 3 affects lake trout (Salvelinus namaycush), resulting in several mass mortality events over the years.[2]

Background

The virus was initially identified in 1988 when investigating the cause behind the mass mortalities of cultured juvenile lake trout within two hatcheries located in the Great Lakes region of the United States.[3] By the end of the 1980s, 15 million lake trout had died due to the virus in the Laurentian Great Lakes Basin.[4][5] Hatcheries removed the infected fish and heavily sanitized the contaminated areas in order to prevent further spread of the virus. However, a northern Michigan hatchery experienced two outbreaks in 2012 and 2017, resulting in the loss of approximately 100,000 lake trout, indicating that the threat of Salmonid herpesvirus 3 is still present, possibly due to infected wild lake trout being introduced to the hatcheries for breeding.[4]

Pathology

Salmonid herpesvirus 3 has been found to target

Viral DNA has not been found to be present in the internal organs until at least two weeks post-infection.[4] As the disease progresses, the skin of the fish is shed, leading researchers to believe the ulcerated, necrotic
tissue of infected fish being the primary source of infection to neighbouring fish. Skin, eye, and gill tissue contain a higher amount of virus-positive DNA than internal organ tissue throughout all stages of infection.

Clinical signs indicating infection of the virus include fin congestion, corneal opacity, skin lesions (including ulceration), gill pallor, and erythema.[4]

PCR and qPCR assays have been developed in order to detect the presence of the virus during active viral outbreaks and latent states of infection in lake trout from kidney, skin, ovarian fluid. The earliest detection of the virus in infected fish was experimentally found to be by day 9.[7]

Treatment

There are currently no treatments or vaccines for Salmonid herpesvirus-3, however prevention measures such as the usage of potassium peroxymonosulfate (PPMS)-based disinfectants on hatchery tools have been utilized to minimize loss of hatchery-raised lake trout.[8]

References

  1. ^ "ICTV Master Species List 2018b.v2". International Committee on Taxonomy of Viruses (ICTV). Archived from the original on March 30, 2019. Retrieved 19 June 2019.
  2. ^
    ISSN 0177-5103
    .
  3. ISSN 0177-5103
    .
  4. ^
    PMID 32744164
    .
  5. ISSN 0177-5103
    .
  6. PMID 31247927
    .
  7. PMID 26980561
    .
  8. PMID 34207532
    .
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