Sapanisertib

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Sapanisertib
Identifiers
  • 5-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine
JSmol)
  • CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N
  • InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
  • Key:GYLDXIAOMVERTK-UHFFFAOYSA-N

Sapanisertib (also known as MLN0128, INK128 and TAK-228) is an experimental small molecule inhibitor of mTOR which is administered orally. It targets both mTORC1 and mTORC2.[1]

Developed by

phase II clinical trials for breast cancer, endometrial cancer, glioblastoma, renal cell carcinoma, and thyroid cancer.[5] The drug has been well tolerated by patients with advanced solid tumours in Phase I trials.[6]

References

  1. S2CID 54344624
    .
  2. PMID 30699367
    .
  3. PMID 31749911
    .
  4. PMID 31841591
    .
  5. ^ "Sapanisertib - Takeda Oncology". Adis Insight. Springer Nature Switzerland AG.
  6. PMID 29464110
    .
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