Small Cajal body specific RNA 15
| Small Cajal body specific RNA 15 | |
|---|---|
| SO | SO:0000275 |
| PDB structures | PDBe |
Small Cajal body specific RNA 15 (also known as SCARNA15 or ACA45) is a
.scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
ACA45 belongs to the
H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1.[2] ACA45 is predicted to guide the pseudouridylation of residue U37 of the U2 spliceosomal snRNA.[3]
It has been shown that human ACA45 can be processed into a 21
RNAse III family endoribonuclease dicer.[4] This snoRNA product has previously been identified as mmu-miR-1839[5] and was shown to be processed independent of the other miRNA generating endoribonuclease drosha.[6]
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