Uridine
Names | |
---|---|
IUPAC name
Uridine[1]
| |
Systematic IUPAC name
1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4(1H,3H)-dione | |
Identifiers | |
3D model (
JSmol ) |
|
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard
|
100.000.370 |
IUPHAR/BPS |
|
MeSH | Uridine |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C9H12N2O6 | |
Molar mass | 244.20 |
Appearance | solid |
Density | .99308g/cm3 |
Melting point | 167.2 °C (333.0 °F; 440.3 K) |
log P | -1.98 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Uridine (
Biosynthesis
Uridine is widely produced in nature as
Dietary sources
Uridine is regarded as a non-essential nutrient, as it is produced by the human body as needed and supplementation is not generally recommended, though it has been explored for specific applications.[3]
Some foods that contain uridine in the form of RNA are listed below. Although claimed that virtually none of the uridine in this form is bioavailable "since – as shown by Handschumacher's Laboratory at Yale School of Medicine in 1981[4] – it is destroyed in the liver and gastrointestinal tract, and no food, when consumed, has ever been reliably shown to elevate blood uridine levels'. This is contradicted by Yamamoto et al.,[5] plasma uridine levels rose 1.8-fold 30 minutes after beer ingestion, suggesting, at the very least, conflicting data. On the other hand, ethanol on its own (which is present in beer) increases uridine levels, which may explain the raise of uridine levels in the study by Yamamoto et al.[6] In infants consuming mother's milk or commercial infant formulas, uridine is present as its monophosphate, UMP,[7] which is both bioavailable[8] and able to enter the circulation from the digestive tract.[citation needed]
- goat's and sheep's milk and milk products
- Sugarcane extract[9]
- Tomatoes (0.5 to 1.0 g uridine per kilogram dry weight)[10]
- Brewer's yeast (1.7% uridine by dry weight)[11][12]
- Beer[13]
- Broccoli[11]
- Organ meats (liver, pancreas, etc.)[11]
Consumption of RNA-rich foods may lead to high levels of
Harvard researchers report that omega-3 fatty acids and uridine, two substances in foods such as fish, walnuts, molasses, and sugar beets, prevented depression in rats as effectively as antidepressant drugs. "Giving rats a combination of uridine and omega-3 fatty acids produced immediate effects that were indistinguishable from those caused by giving the rats standard antidepressant medications," said lead author of the study William Carlezon, director of McLean's Behavioral Genetics Laboratory.[15][16]
Galactose glycolysis
Uridine plays a role in the
See also
References
- ISBN 978-0-85404-182-4.
- ^ Berg JM, Tymoczko JL, Stryer L. (2002). "Section 25.1In de Novo Synthesis, the Pyrimidine Ring Is Assembled from Bicarbonate, Aspartate, and Glutamine". Biochemistry (5th ed.). W H Freeman.
{{cite book}}
: CS1 maint: multiple names: authors list (link) - ISBN 9780080958019.
- PMID 7256279.
- PMID 12370853.
- PMID 9160822.
- PMID 24763080.
- PMID 12812153.
- ^ Thebody.com
- PMID 15656671. Archived from the original on 2 October 2011.)
{{cite journal}}
: CS1 maint: unfit URL (link - ^ S2CID 28474801.
- PMID 5848326.
- PMID 12370853.
- ^ "Gout, Hyperuricemia & Chronic Kidney Disease". The National Kidney Foundation. 24 December 2015. Retrieved 24 November 2017.
- ^ "Food ingredients may be as effective as antidepressants". Harvard Gazette. 10 February 2005. Retrieved 9 April 2018.
- S2CID 1834258.
- ^ Stryer, Berg and Tymoczko (2002). "Section 16.1 Glycolysis Is an Energy-Conversion Pathway in Many Organisms". Biochemistry (5th ed.). New York: W H Freeman.