Stepholidine

Source: Wikipedia, the free encyclopedia.
(−)-Stepholidine
Names
IUPAC name
3,9-Dimethoxyberbine-2,10-diol
Systematic IUPAC name
(13aS)-3,9-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,10-diol
Other names
l-Stepholidine
Identifiers
3D model (
JSmol
)
ChEMBL
ChemSpider
MeSH Stepholidine
UNII
  • InChI=1S/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1 ☒N
    Key: JKPISQIIWUONPB-HNNXBMFYSA-N ☒N
  • InChI=1/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
    Key: JKPISQIIWUONPB-HNNXBMFYBD
SMILES
  • COC1=C(C=C2[C@@H]3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O
Properties
C19H21NO4
Molar mass 327.374 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

(−)-Stepholidine is a protoberberine alkaloid found in the plant Stephania intermedia.

Stepholidine activity includes dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies.[1][2][3][4]

See also

References

  1. S2CID 21653956
    .
  2. PMID 18220736
    . Archived from the original on July 20, 2012.
  3. PMID 11804640
    .
  4. PMID 17468175
    .
Retrieved from "https://en.wikipedia.org/w/index.php?title=Stepholidine&oldid=1292283868"