Talk:Ebola
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Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 18 August 2020 and 4 December 2020. Further details are available on the course page. Student editor(s): Aced 24.
Above undated message substituted from
Ebola virus link to T-cell depletion
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Could someone, please, insert the following text into the main article?
A new study done at University of Texas Medical Branch at Galveston sheds new ligh on the way the Ebola virus attacks immune system of the infected person by disabling T cells.
In the said study, it has been demonstrated "that both viral mRNAs and antigens are detectable in CD4+ T cells despite the absence of productive infection. A protein phosphatase 1 inhibitor, 1E7-03, and siRNA-mediated suppression of viral antigens were used to demonstrate de novo synthesis of viral RNAs and antigens in CD4+ T cells, respectively. Cell-to-cell fusion of permissive Huh7 cells with non-permissive Jurkat T cells impaired productive EBOV infection suggesting the presence of a cellular restriction factor." It was "determined that viral transcription is partially impaired in the fusion T cells" and "that exposure of T cells to EBOV resulted in autophagy through activation of ER-stress related pathways. These data indicate that exposure of T cells to EBOV results in an abortive infection, which likely contributes to the lymphopenia observed during EBOV infections."
The above quotes come from:
Patrick Younan, Rodrigo I. Santos, Palaniappan Ramanathan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Tatiana Ammosova, Michelle Meyer, Michael G. Katze, Vsevolod L. Popov, Sergei Nekhai, Alexander Bukreyev. Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection. PLOS Pathogens, 2019; 15 (10): e1008068 DOI: 10.1371/journal.ppat.1008068 — Preceding unsigned comment added by 172.88.197.74 (talk) 16:07, 27 February 2021 (UTC)
- Not done. We much prefer a secondary source for medical articles (see WP:MEDRS). Also, you need to simplify that down into layman terms, aka defining what all of those acronyms mean. ◢ Ganbaruby! (Say hi!) 01:47, 9 March 2021 (UTC)]
Semi-protected edit request on 13 June 2022
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The paragraph directly under the Causes section of the article states that "EVD in humans is caused by four of five viruses of the genus Ebolavirus," and goes on to talk about each of these five variants. The Wikipedia article for Ebolavirus, however, states that there are six different species of in the Genus Ebolavirus, with the addition of Bombali Ebola virus to the five mentioned in the paragraph. All sources used in this paragraph were published prior to this species identification in 2018, and as such would not have listed this species. As such I believe that this section should be updated to include this new species. A suggestion for possible edits (without updated references) to this section is below:
Cause
EVD in humans is caused by four of six viruses of the genus
FATCullen (talk) 04:16, 13 June 2022 (UTC)
References
- ^ a b Cite error: The named reference
Hoenen2012
was invoked but never defined (see the help page). - PMID 21046175.
- ^ Spickler, Anna. "Ebolavirus and Marburgvirus Infections" (PDF). Archived (PDF) from the original on 30 April 2015.
- ^ "About Ebola Virus Disease". Centers for Disease Control and Prevention (CDC). Archived from the original on 16 October 2014. Retrieved 18 October 2014.
Semi-protected edit request on 3 September 2022
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Add a record for the August 22, 2022 Ebola outbreak.
The
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National Road No. 2is the main road in Beni
Placide Mbala also stated, "Our initial findings indicate that this case likely represents a new flare-up of the 2018-2020 North Kivu/Ituri outbreak, initiated by transmission of Ebola virus from a persistently infected survivor or a survivor who experienced a relapsed." Investigations are ongoing to determine the source.[1] According to the statement, at least 131 contacts have been found, including 60 front-line healthcare providers, 59 of whom have received the Ebola vaccine. However, the WHO reports that A total of 134 hospital contacts (60 health care personnel and 74 co-patients) were been identified.[2]
The test was administered using reverse transcription polymerase chain reaction (RT-PCR) testing on oropharyngeal secretions and sent to National Institute for Biomedical Research, Beni, which revealed a positive result. The sample was analyzed at the Rodolphe Mérieux INRB Laboratory in Goma for quality control purposes, and on August 16, 2022, RT-PCR results were confirmed. The body was given to the family before the test findings were known, and it was then buried on August 16, 2022.[1]
The
The re-emergence of Ebola is a significant public health concern in the
The WHO described the national risk as high; however, the regional and global levels were assessed as moderate to low, respectively.[1]
[2] Isacc Barker (talk) 19:46, 3 September 2022 (UTC)
References
- Not done for now: This is written like a news article. Please see WP:NOTNEWS and reopen your request after you have refactored it. Aaron Liu (talk) 11:41, 15 September 2022 (UTC)]
Wiki Education assignment: Plagues and People
This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 August 2023 and 11 December 2023. Further details are available on the course page. Student editor(s): Bridgettemora (article contribs). Peer reviewers: Shy.Mancha13, BrightBuds.
— Assignment last updated by Maxwellmcgowan (talk) 20:37, 26 October 2023 (UTC)