Reston virus

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Reston ebolavirus
An artificially colored
transmission electron micrograph
of the Reston virus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Filoviridae
Genus: Ebolavirus
Species:
Reston ebolavirus
Synonyms

Reston virus (RESTV)

Reston virus (RESTV) is one of six known viruses within the

Ebola virus (EBOV).[4] It is the single member of the species Reston ebolavirus, which is included into the genus Ebolavirus, family Filoviridae, order Mononegavirales.[5] Reston virus is named after Reston, Virginia
, US, where the virus was first discovered.

RESTV was discovered in

Simian hemorrhagic fever virus (SHFV).[8] Despite ongoing research, the determinants for lack of human pathogenicity are yet to be discovered.[9]

Nomenclature

Reston virus was first introduced as a new "strain" of Ebola virus in 1990.[4] In 2000, it received the designation Reston Ebola virus[10][11] and in 2002, the name was changed to Reston ebolavirus.[12][13] Previous abbreviations for the virus were EBOV-R (for Ebola virus Reston) and most recently REBOV (for Reston Ebola virus or Reston ebolavirus). The virus received its current designation in 2010, when it was renamed Reston virus (RESTV).[5]

A virus of the species Reston ebolavirus is a Reston virus (RESTV) if it has the properties of

Reston ebolaviruses and if its genome diverges from that of the prototype Reston virus. For example, there exists Reston virus variant Pennsylvania (RESTV/Pen), differing by less than 10% at the nucleotide level.[5]

History

Discovery

While investigating an outbreak of

Hazleton Laboratories in Reston, Virginia. The filovirus was further isolated by Dr. Peter Jahrling, and over the period of three months over a third of the monkeys died—at a rate of two or three a day.[14]

Blood samples were taken from 178 animal handlers during the incident.

Cynomolgus. Under the direction of the Centers for Disease Control and Prevention (CDC), the animal handler was placed under surveillance for the duration of the incubation period. When the animal handler failed to become ill, it was concluded that the virus had a low pathogenicity in humans.[16]

Investigation

Crab-eating macaques, imported from the Philippines, were found to be carrying the filovirus.

Following the discovery of a

filovirus in crab-eating macaques, an investigation tracing the infection was conducted by the CDC. The monkeys were imported from the Philippines, which had no previous record of SHFV or ebolavirus infections. It was suspected that the monkeys contracted both diseases while in transit aboard KLM Airlines before reaching Reston. Shipments were tracked to New York City, Texas, and Mexico City, none of which produced cases of infection.[17]

By January 1990, Hazelton Laboratories recovered from its previous losses and began importing monkeys again from the same establishment in Manila that had provided the original animals. The imported monkeys became infected and were euthanized.[15] In early February the CDC received reports of the disease in Alice, Texas. In March, the Division of Quarantine at the CDC secured a temporary ban on the importation of monkeys into the United States from anywhere in the world.[18]

Following the announcement of the filovirus disease outbreak in Reston, Virginia, a

serosurvey was conducted to assess the prevalence of the infection. Of the several hundred serums received by the CDC, approximately ten percent showed some reaction to ebolavirus antigen—though usually at low levels. Counterintuitively, the majority of the monkeys found positive were from Indonesia.[19]

In May 1990, an investigation led by Susan Fisher-Hoch, Steve Ostroff, and Jerry Jennings was sent to Indonesia. During the investigation, it was hypothesized that there could be a cross infection since monkeys suspected of illness were typically placed in gang cages containing up to twenty to thirty other monkeys suspected of illness. Upon arrival they were told that most of the monkeys were imported from the island of Sumatra. The investigation team found no trace of the virus in either case.[20]

Following the investigation in Indonesia, an experiment was conducted in the level-4 lab at the CDC campus in DeKalb County, Georgia with thirty-two monkeys: sixteen green monkeys (Cercopithecus aethiops) and sixteen crab-eating macaques. Half of the sixteen green monkeys and crab-eating macaques were infected with Reston virus and the other half with Ebola virus. Ebola virus infection was lethal to nearly all monkeys. However, most of the monkeys infected with Reston virus recovered in a month. The surviving monkeys were kept for two years to detect any trace of the virus - none was found. However, the monkeys continued to possess a high level of antibody.[8]

Post-Reston

Following the test at the CDC campus in DeKalb County, two of the monkeys who had survived Reston virus infection were infected with a very large dose of the Ebola virus in an effort to produce an Ebola vaccine. One of the two monkeys remained resistant; the second died.[8]

The physical building in which the outbreak occurred was demolished on 30 May 1995 and a daycare center was constructed in its place.[21] Modern spatial computer simulation indicates that the pathogen could have reached both major airports (Dulles International Airport and Ronald Reagan Washington National Airport) in less than 45 minutes assuming direct transmission paths.[22]

Outbreaks and cases

See also: List of Ebola outbreaks
  • 1989 –1990 Philippines – High mortality among crab-eating macaques in a primate facility responsible for exporting animals in the United States.[23] Three workers in the facility developed antibodies but did not get sick.[24]
  • 1989 Reston, Virginia, United States – RESTV was introduced into quarantine facilities in Virginia and Pennsylvania by monkeys imported from the Philippines.[14]
  • 1989–1990 – RESTV was introduced into quarantine facilities in Texas by monkeys imported from the Philippines. Four humans developed antibodies but did not get sick.[9][25]
  • 1996 Alice, Texas, United States – An outbreak occurred at the Texas Primate Center that imported monkeys from the Philippines.[26]
  • 2008 Manila, Philippines – On 11 December 2008, pigs from farms slightly north of Manila, Philippines tested positive for the virus. The CDC and the World Health Organization are investigating.[27] On 23 January 2009, Philippine health officials announced that a hog farm worker had been infected with the virus. Although the man was asymptomatic and the source of the infection is uncertain, this could represent the first case of pig-to-human transmission of Reston virus – a fact that could cause concern, as pigs may be able to transmit more deadly diseases to humans. The situation was investigated.[28] Eventually six workers were found to test sero-positive for antibodies to Reston ebolavirus. None developed any noticeable symptoms of illness.[29]
  • 2015 Manila, Philippines – On 6 September the department of health reported an outbreak of the Reston Ebola virus in a research breeding facility under primates. Twenty-five workers were tested for the virus. All of the workers tested negative for the disease.[30]

In popular culture

References

  1. ^ Spickler, Anna. "Ebolavirus and Marburgvirus Infections" (PDF).
  2. ^ "About Ebola Virus Disease". CDC. Retrieved 18 October 2014.
  3. ^ "Years of Ebola Virus Disease Outbreaks | 2014-2016 Outbreak West Africa | History | Ebola (Ebola Virus Disease) | CDC". 2018-11-09.
  4. ^
    PMID 2229429
    .
  5. ^
    PMID 21046175
    .
  6. ^ Special Pathogens Branch CDC (2008-01-14). "Known Cases and Outbreaks of Ebola Hemorrhagic Fever". Centers for Disease Control and Prevention. Archived from the original on 2008-08-29. Retrieved 2008-08-02.
  7. ^ McCormick & Fisher-Hoch 1999, p. 300
  8. ^ a b c McCormick & Fisher-Hoch 1999, pp. 307–309
  9. ^
    PMID 28066813
    .
  10. ISBN 978-0-12-370200-5
    .
  11. S2CID 13229117
    .
  12. ISBN 978-0-12-370200-5
    .
  13. S2CID 43887711
    .
  14. ^ a b McCormick & Fisher-Hoch 1999, pp. 277–279
  15. ^ a b Waterman, Tara (1999). "Ebola Reston Outbreak Stanford Honors Thesis". Stanford University. Retrieved 2008-08-02.
  16. ^ McCormick & Fisher-Hoch 1999, pp. 298–299
  17. ^ McCormick & Fisher-Hoch 1999, pp. 286–289
  18. ^ McCormick & Fisher-Hoch 1999, pp. 294–295
  19. ^ McCormick & Fisher-Hoch 1999, pp. 302–303
  20. ^ McCormick & Fisher-Hoch 1999, pp. 304–305
  21. ^ "Isaac Newton Metro KinderCare | Daycare, Preschool & Early Education in Reston, VA | KinderCare".
  22. ISBN 978-0-323-95389-4
    , retrieved 2023-03-05
  23. PMID 1621890
    .
  24. S2CID 28273498
    .
  25. PMID 2107388
    . Retrieved 4 August 2021.
  26. ^ Lianne Hart (23 April 1996). "MEDICINE : Texas Ebola Scare Is Over, but Coast Isn't Completely Clear". Los Angeles Times.
  27. ^ Gale, Jason (2008-12-11). "Pig Ebola May Lead Scientists to 'Elusive Reservoir' of Virus". New York City: Bloomberg L.P. Retrieved 2008-12-22.
  28. ^ McNeil Jr, Donald G. (2009-01-24). "Pig-to-Human Ebola Case Suspected in Philippines". The New York Times. Retrieved 2009-01-26.
  29. PMID 19590002
    .
  30. ^ "Philippine monkeys infected with Ebola not lethal to humans". News 24. 23 April 1996. Retrieved 6 September 2014.
  31. OCLC 32052009. At Google Books.
    (2) "Best Sellers: June 4, 1995". The New York Times Book Review. New York. 1995-06-04. Retrieved 2014-09-10.
    (3) "About The Hot Zone"
    . Random House. Retrieved 2014-09-10.

Bibliography

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