Ten Feizi
Ten Feizi Royal Free Medical School | |
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Scientific career | |
Institutions | Imperial College London Columbia University Rockefeller University Hammersmith Hospital |
Thesis | Cold agglutinins and mycoplasma pneumoniae (1969) |
Ten Feizi FMedSci FRS (born in 1937[1]) is a Turkish Cypriot/British molecular biologist who is Professor and Director of the Glycosciences Laboratory at Imperial College London. Her research considers the structure and function of glycans. She was awarded the Society for Glycobiology Rosalind Kornfeld award in 2014. She was also awarded the Fellowship of the Academy of Medical Sciences in 2021.
Early life and education
Born in
Research and career
In 1973 Feizi joined the Medical Research Council Clinical Research Centre, where she was appointed Head of the Glycoconjugates Section. She eventually established the Imperial College London Glycosciences Laboratory.[4] She was made a Professor at Imperial College London in 1994.[4]
Her early research considered cold agglutinins, sensitive, misdirected antibodies that build up following mycoplasma pneumoniae. The antigen on red blood cells that is bound by these cold agglutinins is known as the
Feizi showed that during both cellular differentiation and the transformation of normal cells to tumorous cells, anti-li blood group antibodies could be used to track changes in glycosylation.[7][10] She studied the ability of animal lectins to bind to oligosaccharides.[7] Her interest in both the structure and recognition of glycans led her to develop a new glycan screening protocol. Feizi created the neoglycolipid (NGL)-based oligosaccharide microarray system, which allowed her to explore the whole spectrum of glycans, specific cells and glycoproteins.[7][11][12] In 2002 her system was the first to encompass entire glycomes.[3] Her glycoarray system, which is supported by the Wellcome Trust, is one of the world's most diverse, which allows better understanding of host–pathogen interactions and the interactions between glycans and proteins in disease processes.[5][3][13] The system was used to assign the host-cell receptors in SV40 and Influenza A virus subtype H1N1.[14][15]
Awards
- 1994 American Society for Clinical Pathology Outstanding Research Award[16]
- 2014 Society for Glycobiology Rosalind Kornfeld Lifetime Achievement Award[7][5]
- 2020 Royal Society of Chemistry Carbohydrate Group Haworth Memorial Lectureship[17]
She is a Fellow of the Academy of Medical Sciences, the Royal College of Physicians and the Royal College of Pathologists.[citation needed] In May 2021 she was elected Fellow of the Royal Society.[18]
Selected publications
- Feizi, Ten (1985). "Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens". Nature. 314 (6006): 53–57. S2CID 4257789.
- Fukui, Shigeyuki; Feizi, Ten; Galustian, Christine; Lawson, Alexander M.; Chai, Wengang (3 September 2002). "Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions". Nature Biotechnology. 20 (10): 1011–1017. S2CID 19655076.
- Stamatatos, Leo; Sather, Noah (18 November 2011). "Faculty of 1000 evaluation for A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield". )
References
- ^ a b c d Pioneering Turkish Cypriot scientist awarded prestigious fellowship of the Royal Society, T-Vine, 2021, retrieved 19 May 2021,
Lefkoşa-born Professor Feizi... Born in 1937, Ten Feizi completed her primary and secondary schooling in Cyprus before moving to London to continue her studies.
- ^ Kıbrıslı Türk bilim insanı Prof.Dr. Ten Feizi'ye "Fellow of Royal Society" unvanı, Kıbrıs Genç TV, 2021, retrieved 19 May 2021
- ^ a b c "Home - Professor Ten Feizi". www.imperial.ac.uk. Retrieved 19 March 2020.
- ^ OCLC 4779868487.
- ^ a b c d e f g "Professor Ten Feizi wins Society for Glycobiology lifetime achievement award | Imperial News | Imperial College London". Imperial News. Retrieved 19 March 2020.
- OCLC 926243918.
- ^ a b c d e f g "Dr. Ten Feizi wins 2014 Rosalind Kornfeld Award". Society for Glycobiology. Retrieved 19 March 2020.
- PMID 2845957.
- S2CID 35223037.
- S2CID 4257789.
- ^ "Carbohydrate microarrays". Imperial College London. Retrieved 19 March 2020.
- ^ "Carbohydrate Microarray Facility". Imperial College London. Retrieved 19 March 2020.
- ^ "Current composition of NGL-based microarrays". Glyosciences Laboratory. Retrieved 19 March 2020.
- PMID 19741625.
- ^ "Wang - SRI International". Division of Cancer Prevention. 20 December 2016. Retrieved 19 March 2020.
- ISSN 0959-6658.
- ^ "2020 Haworth Memorial Lectureship". Royal Society of Chemistry. Retrieved 20 April 2020.
- ^ "Royal Society elects outstanding new Fellows and Foreign Members". The Royal Society. 6 May 2021. Retrieved 21 May 2021.