Trichomonas

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Trichomonas
Two trophozoites of "Trichomonas vaginalis" stained with Giemsa
Two
Giemsa
Scientific classification Edit this classification
Domain: Eukaryota
Phylum: Metamonada
Subphylum: Trichozoa
(unranked): Parabasalia
Order: Trichomonadida
Family: Trichomonadidae
Genus: Trichomonas
Species[1]

Trichomonas is a genus of

Monas.[2]

Habitat and ecology

Trichomonas is typically found in

urogenital tract and in the oral cavity. It is estimated that 276 million new cases of urogenital infections occur each year.[3][5][6] Depending on the Trichomonas species, it can either be transmitted through direct sexual contact or through contaminated water sources.[3][5][6] In birds, it can be found in the upper digestive tract and is transmitted when adult birds regurgitate food to feed their young, when a bird of prey feeds on an infected bird, and through contaminated food or water.[7]

Morphology

Trichomonas is around 10 µm in length and is normally pear-shaped. It has four

microtubules that curve around the flagellar bases. Posterior to the pelta is the axostyle, is a bundle of microtubules that extends from the anterior end of the organism all the way to the posterior end. The nucleus of Trichomonas is situated close to where the pelta and axostyle meet.[7][6][8][9]

Another distinguishing feature of Trichomonas is the presence of an undulating membrane. The undulating membrane is a fin-like extension of the plasma membrane located on the side of the organism. A flagellum that extends to the posterior end of the organism is attached to the outer edge of the undulating membrane. At the base of the undulating membrane is a striated fiber called the costa which is thought to exist for structural support.[7][10][6][8][9]

Trichomonas has a very interesting

pyruvate:ferredoxin oxido-reductase and hydrogenase to produce ATP from pyruvate, generating hydrogen gas as a by-product.[11]

Genetics

Trichomonas vaginalis, being the species that causes the most complications in humans, is the only fully sequenced Trichomonas species. Through whole-genome shotgun sequencing, the Trichomonas vaginalis genome is estimated to be around 160 Mb long, divided into six chromosomes. However, at least 65% of its genome was found to be redundant. The redundant genetic material is hypothesized to have emerged during Trichomonas's transition from aerobic to anaerobic environments.[12]

In addition to discovering the large proportion of

protein-coding genes were found. Transfer RNAs for all 20 amino acids and approximately 250 ribosomal RNA were all found on the same chromosome.[12]

Life cycle

Trichomonas has a

vacuoles, giving the impression of a cystic form. However, due to the lack of a cystic wall surrounding the organism, many studies describe this form as a pseudocystic form.[7][6]

In its trophozoite form, Trichomonas undergoes cell division through an interesting process called cryptopleuromitosis. There are three common forms of

chromosomes. In closed mitosis, the nuclear envelope does not disappear but mitotic spindles appear within the nucleus to separate the chromosomes. In semi-open mitosis, the nuclear envelope remains intact but the mitotic spindles pierce through the nuclear envelope to divide the chromosomes. Cryptopleuromitosis is different from all the other more commonly known methods of cell division. In cryptopleuromitosis, the chromosomes divide without the breakdown of the nuclear envelope and without the entry of mitotic spindles into the nucleus.[13]

Diseases

Trichomonas causes disease in humans and in birds. In humans, the causative species is Trichomonas vaginalis and Trichomonas tenax.[3][5][6] In birds, the causative species are Trichomonas gallinae, Trichomonas gypactinii, and Trichomonas stableri.[14][15][7]

In humans

Trichomonas vaginalis is a sexually transmitted disease and causes trichomoniasis. It resides on squamous epithelium of the urogenital tract. Many carriers of Trichomonas vaginalis, especially men, are asymptomatic. Complications for symptomatic women include vaginitis, endometritis, infertility, and cervical cancer. Complications for symptomatic men include urethritis, prostatitis, epididymitis, and infertility. It is also associated with increased risk of transmission and acquisition of HIV.[5][6]

Trichomonas tenax is transmitted through exchange of saliva and contaminated water sources. It is an opportunistic pathogen and may cause pulmonary trichomoniasis.[3]

In birds

Trichomonas in birds inhabit the upper digestive tract and also cause trichomoniasis. It creates lesions in the trachea and esophagus, occupying space and eventually causing emaciation and asphyxiation.[14][15][7]

Species

References

  1. ^ "Trichomonas". NCBI taxonomy. Bethesda, MD: National Center for Biotechnology Information. Retrieved 4 February 2019.
  2. ^ Donné, A. (19 September 1836). "Animalcules observés dans les matières purulentes et le produit des sécrétions des organes génitaux de l'homme et de la femme". Comptes Rendus Hebdomadaires des Séances de l'Académie des Sciences (in French). 3: 385–386.
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