User:Arizzo0226/sandbox
Article Evaluation
For this assignment, I decided to evaluate the article on hypothyroidism. After reviewing the article, I was pleasantly surprised by the organization of the article itself. I thought that it followed a very logical order and that the main endocrinology concepts were paired with great visuals to help readers understand the content. I believe there is room for improvement in the figure captions describing symptoms of patients with the condition. I noticed grammar mistakes and missing punctuation. While many of the sources were fairly recent publications, I noticed that the information regarding Myxoedema were older. The two sources used for this content were published in 1891 and 1892. Thus, if I were editing this article I would try to find more up-to-date sources. The overall tone of the article was neutral and informative; there were no signs of personal opinion ined the writing. After reading the article I viewed the talk page to see what conversation was taking place regarding the content and layout. The last advertised edits to the article were made in April 2017. Some of the discussion taking place seems to revolve around finding more adequate sources to support the information presented by the authors.
Potential Articles
1) Carbimazole: The article could be improved by finding more sources. This article has not been verified by Wikipedia yet because the author did not cite the information used. I find this topic interesting and would like to know more about its course of action and how it is used as a treatment for hyperthyroidism. Additionally I think showing a diagram of how the drug interacts with thyroid peroxidase would be useful to readers. Visuals typically help with understanding complex biological processes.
2) Jod-Basedow Phenomenon: The article could be improves by finding more sources. It appears that the author only used one source. I have heard of thyroid problems when too much iodine is taken by an individual. I believe that the thyroid can become dysfunctional if too much iodine is introduced. Including more about why this phenomenon happens, what research has been done on the topic, and potential implications would improve this article drastically. This is definitely something I am interested in moving forward.
3) Thyroid Hormone Receptor: This article may indeed be what I ultimately land on editing. I love finding out more on receptors and the way that they word, so this is definitely intriguing to me. This article needs more information on the differences between receptor types. Additionally, it could benefit largely from additionally sources and more images showing hormone action at the level of the receptors themselves. As it stands, there are not any sources citing the information on the receptors in their active or inactive states. This is likely a large contributor to why the article has not officially been published on Wikipedia.
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ARTICLE TO DO LIST:
-Function section needs more sources and more information in general
-Mechanism of action would be improved with a visual
-Isoforms section needs more information on each subtype
-Disease linkage needs more sources and more information; could also benefit from visuals of potential symptoms
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The thyroid hormone receptor (TR)
Structure
There are four
Function
Thyroid hormone receptors play critical roles in the regulation of metabolism, heart rate, and development of organisms.[5][6][7] TRs are also involved in cell viability, and are believed to have other non-genomic affects that are currently being investigated.[3]
Mechanism of action
Thyroid hormone can have genomic or non-genomic effects.[3] The genomic signaling pathway directly influences gene transcription and translation, while the non-genomic pathway involves more rapid, cellular changes.
Genomic Signaling Pathway
Thyroid hormone receptors
In the absence of hormone, TR in complex with corepressor proteins bind to HREs in a transcriptionally inactive state.[3] Binding of thyroid hormone results in a conformational change in TR which displaces corepressor from the receptor/DNA complex and recruitment of coactivator proteins. The DNA/TR/coactivator complex then recruits RNA polymerase that transcribes downstream DNA into messenger RNA and eventually protein that results in a change in cell function.
Non-genomic Signaling Pathway
Non-genomic TR signaling is still being investigated, however, TR-α1 (a specific
Isoforms
There are two main classes of the
Isoform | Common Location of Expression |
---|---|
TR-α1 | widely expressed; especially high expression in cardiac and skeletal muscles and bone |
TR-α2 | widely expressed; high expression in skeletal muscles, brain, and kidney |
TR-α3 | widely expressed; high expression in skeletal muscle, brain, and kidney |
TR-β1 | predominately in brain, liver, and kidney |
TR-β2 | primarily limited to the retina, hypothalamus, pituitary, and cochlea |
TR-β3 | N/A |
Disease linkage
Certain mutations in the thyroid hormone receptor are associated with thyroid hormone resistance.[9] Mutations in the THRB gene can change the shape of the TR binding site, lowering its affinity for thyroid hormone.[10] This change in affinity can have detrimental effects on metabolism, growth, and development.
References
- PMID 6323162.
- PMID 17132849.
- ^ ISBN 978-1-4557-4858-7.
- ^ ISSN 1759-5029.
- PMID 11427693.
- PMID 12165104.
- PMID 11704989.
- ^ PMID 1310351.
- PMID 17132274.
- ISBN 978-0-323-29738-7.
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