User:Onceler/Sandbox9

Source: Wikipedia, the free encyclopedia.

Classification

Structural homology has been able to partially distinguish between cytokines that do not demonstrate a considerable degree of redundancy so that they can be classified into four types:

  • The four α-helix bundle family - Member cytokines have three-dimensional structures with four bundles of α-helices. This family in turn is divided into three sub-families:
    1. the IL-2 subfamily
    2. the intterferon (INF) subfamily
    3. the IL-10 subfamily
    The first of these three subfamilies is the largest. It contains several non-immunological cytokines including erythropoietin (EPO) and thrombopoietin (THPO). Alternatively, four α-helix bundle cytokines can be grouped into long chain and short chain cytokines.
  • the
    IL-1 family - It primarily includes IL-1 and IL-18
    .
  • the IL-17 family - It has yet to be completely characterised, though member cytokines have a specific effect in promoting proliferation of T-cells that cause cytotoxic effects.
  • Chemokines

A more clinically and experimentally useful classification divides immunological cytokines into those that promote the proliferation and functioning of helper T-cells, type 1 (IL-1, INF-γ etc.) and type 2 (IL-4, IL-10, IL-13, TGF-β etc.), respectively. A key focus of interest has been that cytokines in one of these two sub-sets tend to inhibit the effects of those in the other. This tendency is under intensive study for its possible role in the pathogenesis of autoimmune disorders.


Index

Sandboxes
Archives

Useful links

Editing:

Canned:
Citations:
Copyright:
Footnotes:
General:
Redirects/Disambiguation:
Sections:
Tables:
Visuals:
  • Hex triplet colors
  • Wikipedia:Picture_tutorial
W:MOS:
  • Wikipedia:Manual of Style (dates and numbers)#Avoid overlinking dates
  • Wikipedia:Manual of Style (dates and numbers)#Usage of links for date preferences
  • Wikipedia:Manual of Style (dates and numbers)
  • Wikipedia:Manual_of_Style
  • Wikipedia:Manual_of_Style_(titles)
  • Strains of writer's malaise I'm developing antibodies for:
  • Wikipedia:Manual_of_Style_(dashes)
  • Wikipedia:Cite_sources

Other:

Current Information:
Email:
Ethics/Conventions/Practices:
  • Wikipedia:Revert
Hmmm:
Policy:
Search References:
Search Tools:
Statistics:
Translation:
Wikipedia:
Tools:
Miscellaneous
Retrieved from "https://en.wikipedia.org/w/index.php?title=User:Onceler/Sandbox9&oldid=62782663"