Visual processing abnormalities in schizophrenia
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Visual processing abnormalities in schizophrenia are commonly found, and contribute to poor social function.[1]
There is evidence that
Perception of contrast
Contrast sensitivity
Contrast is a feature of visual stimuli that characterizes the difference in brightness between dark and light regions of an image. Perception of contrast is affected by the temporal frequency and spatial frequency properties of a stimulus, and the sensitivity to contrast in sine wave stimuli is characterized by the contrast sensitivity function. Contrast sensitivity has been shown to be impaired in schizophrenia.[7][8][9][10] There is evidence that these impairments may be more severe among people with predominantly negative symptoms,[8][9] or those who are not medicated.[10]
Butler and colleagues
Surround suppression
The perceived contrast of a stimulus is sometimes suppressed when another stimulus is presented surrounding it, an effect known as
Motion processing
Inhibition of motion perception by the addition of a surround stimulus has also been examined in schizophrenia, with one group finding evidence both of impaired motion perception and weaker perceptual suppression effects in schizophrenia.[22] This agrees with the findings mentioned previously related to weaker suppression of perceived contrast in this disorder.[13][14][15] However, another recent report has disputed this finding, instead showing evidence consistent with stronger surround influence on motion perception in schizophrenia.[21]Eye movements
Contour detection
Detecting visual contours, edges, or boundaries is an important function in human and
Presentation of collinear stimuli flanking a target can enhance responses to the target in cortex, an effect known as flanker or collinear facilitation, which has been shown to be weaker in those with schizophrenia than in unaffected adults or those with
Crowding phenomenon
Crowding refers to the phenomenon where recognition of visual stimuli presented in the periphery is impaired by the presence of other nearby objects (sometimes called "flankers"). Abnormal crowding has been observed in schizophrenia, with different groups reporting stronger[32] or weaker[33][medical citation needed] crowding effects.
Gaze shifts
During
Perception of faces and facial emotions
Faces
Facial emotions
Recognizing emotional expressions in images of human faces is a particularly important component of face perception with clear implications in human social interactions. People with schizophrenia reportedly perform poorly compared with healthy adults when asked to identify facial emotions.[3][4][5][39] Some researchers have claimed that this is not a deficit specific to facial emotion perception per se, but rather evidence of a generalized deficit or overall poorer task performance in schizophrenia.[3][4] However, others have argued that a review of the literature shows evidence of an additional specific deficit in processing negative emotions, such as anger and fear, among those with schizophrenia.[5] In addition, evidence has been presented of a link between a specific emotion processing deficit in schizophrenia and the volume of temporal lobe structures, including fusiform gyrus and middle temporal gyrus, as measured using MRI.[39]
Visual backward masking
In visual backward masking (VBM) a briefly presented target is followed by a mask, which decreases performance on the target.[40] VBM is a powerful experiment for schizophrenia research.[41] It allows for control over timing at millisecond level, there are well-supported theories of the underlying mechanisms, and it can be easily studied using EEG and fMRI.[42] Not only patients but also their unaffected siblings show strong and reproducible masking deficits, thus masking deficits have been suggested as an endophenotype for schizophrenia.[42][43][44]
Trigger hypothesis
In the early stages of the disease, and in untreated patients, hypersensitivity to low spatial frequencies has been documented. During the further course (and medication) of schizophrenia, this hypersensitivity turns into hyposensitivity and begins to affect other spatial frequencies of visual perception. Alterations to the visual signal, which are largely inconsistent over the course of schizophrenia (remission and relapse phases), may lead to the formation of inconsistent internal models of the world. These signal alterations (noise-to-signal ratios) are associated with fluctuations in Dopamine and Acetylcholin levels, decreased activity of inhibitory GABAergic interneurons, and hypofunction of NMDAr associated with gradual loss of cell populations in the precortical visual circuit. The volatile and noisy signal from the visual periphery may then act as an amplifier of primarily decreased connectivity within frontal areas, which may then prograde retrogradely to lower cortical areas of the visual information processing circuit.[45]
See also
- Mechanisms of schizophrenia
- Causes of schizophrenia
- Diagnosis of schizophrenia
- Visual perception
- Visual system
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