Voxel-based morphometry
Voxel-based morphometry is a computational approach to neuroanatomy that measures differences in local concentrations of brain tissue, through a voxel-wise comparison of multiple brain images.[1]
In traditional
However, VBM can be sensitive to various artifacts, which include misalignment of brain structures, misclassification of tissue types, differences in folding patterns and in cortical thickness.[2] All these may confound the statistical analysis and either decrease the sensitivity to true volumetric effects, or increase the chance of false positives. For the cerebral cortex, it has been shown that volume differences identified with VBM may reflect mostly differences in surface area of the cortex, than in cortical thickness.[3][4]
History
Over the past two decades, hundreds of studies have shed light on the neuroanatomical structural correlates of neurological and psychiatric disorders. Many of these studies were performed using voxel-based morphometry (VBM), a whole-brain technique for characterizing between groups' regional volume and tissue concentration differences from structural magnetic resonance imaging (MRI) scans.[5]
One of the first VBM studies and one that came to attention in mainstream media was a study on the
Another famous VBM paper was a study on the effect of age on gray and white matter and CSF of 465 normal adults.[7] The VBM analysis showed global gray matter was decreased linearly with age, especially for men, whereas global white matter did not decline with age.
A key description of the methodology of voxel-based morphometry is Voxel-Based Morphometry—The Methods[8]—one of the most cited articles in the journal NeuroImage.[9] The usual approach for statistical analysis is mass-univariate (analysis of each voxel separately), but pattern recognition may also be used, e.g., for classifying patients from healthy.[10]
For brain asymmetry
Usually VBM is performed for examining differences across subjects, but it may also be used to examine neuroanatomical differences between hemispheres detecting brain asymmetry.[11][12] A technical procedure for such an investigation may use the following steps:[13]
- Construction of a study-specific brain image template with a balanced set of left and right handed and males and females.
- Construction of segmentation.
- Construction of symmetric grey and white matter templates by averaging right and left cerebral hemispheres.
- Segmentation and extraction of brain image, e.g., removal of scalp tissue in the image.
- Spatial normalization to the symmetric templates
- Correction for volume change (applying a Jacobian determinant)
- Spatial smoothing (intensity in each voxel is a local weighted average generally expressed as GM, WM, CSF concentration).
- Actual statistical analysis by the general linear model, i.e., statistical parametric mapping.
The outcome of these steps is a statistical parametric map, highlighting all voxels of the brain where intensities (volume or GM concentration depending on whether the modulation step has been applied or not) in a group images are significantly lower/higher than those in the other group under investigation.
Compared to the region of interest approach
Before the advent of VBM, the manual delineation of region of interest was the gold standard for measuring the volume of brain structures. However, compared to the region of interest approach, VBM presents a large number of advantages that explain its wide popularity within the neuroimaging community. Indeed, it is an automated and relatively easy-to–use, time-efficient, whole-brain tool that could detect the focal microstructural differences in brain anatomy in vivo between groups of individuals without requiring any a priori decision concerning which structure to evaluate. Moreover, VBM exhibits comparable accuracy to manual volumetry. Indeed, several studies have shown good correspondence between the two techniques, providing confidence in the biological validity of the VBM approach.[14]
See also
References
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- PMID 20006715.
- . Retrieved 19 May 2016.
- PMID 10716738.) Commentary on the original article in the same issue:
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: CS1 maint: multiple names: authors list (link- Alejandro Terrazas & Bruce L. McNaughton (2000). "Brain growth and the cognitive map". PMID 10781031.
- BBC (2000-03-14). "Taxi drivers' brains 'grow' on the job". BBC News. Retrieved 2007-03-06.
- Alejandro Terrazas & Bruce L. McNaughton (2000). "Brain growth and the cognitive map".
- S2CID 6392260.)
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- ^ The number of citations is apparent from a search with Google Scholar (2007-12-07) [1].
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: CS1 maint: multiple names: authors list (link - PMID 11532891.)
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: CS1 maint: multiple names: authors list (link - S2CID 16235256.)
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: CS1 maint: multiple names: authors list (link - .