Zuzana Kečkéšová

Source: Wikipedia, the free encyclopedia.
Zuzana Kečkéšová
Alma mater
Charles University in Prague
University College London
Scientific career
InstitutionsCzech Academy of Sciences
Massachusetts Institute of Technology
Academic advisorsRobert Weinberg

Zuzana Kečkéšová (born 1980) is a Slovak-American molecular biologist at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences. She investigates the reasons that certain organs are protected from cancer.

Early life and education

Kečkéšová is from

retroviral infections and was awarded the Qiagen Award.[1] During her PhD, she spent a year at Columbia University where she looked at post-translational modifications of retroviral restriction factors.[1]

Research and career

After earning her doctorate, Kečkéšová joined the laboratory of

cancer metastasis and the mechanisms of tumour growth.[3][4] She joined the Institute of Organic Chemistry and Biochemistry (IOCB) of the Czech Academy of Sciences in 2017.[5] Kečkéšová discovered that the protein LACTB can act as a tumour suppressant.[1][2][3] She demonstrated that activation of LACTB in cancer cells can result in the death of cells; by altering the composition of lipids in cancer mitochondria.[1]

She was awarded a European Molecular Biology Organization (EMBO) Installation Grant to study the vulnerabilities of cancer cells in 2017.[6] In 2018 Kečkéšová was awarded a €1.75 million grant from BTCZ Ventures to support her research into the mechanisms by which cancer impacts the human body.[7] Under the collaboration, Kečkéšová will retain rights to the intellectual property of her research, whilst BTCZ will own licenses for future patents.[7]

Selected publications

Her publications include:

  • Keckesova, Zuzana (2017). "LACTB is a tumour suppressor that modulates lipid metabolism and cell state". Nature. 543 (7647). et al.: 681–686.
    PMID 28329758
    .
  • Guo, Wenjun (2012). "Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State". Cell. 148 (5). et al.: 1015–1028.
    PMID 22385965
    .
  • Keckesova, Zuzana (2006). "Cyclophilin A Renders Human Immunodeficiency Virus Type 1 Sensitive to Old World Monkey but Not Human TRIM5α Antiviral Activity". Journal of Virology. 80 (10). et al.: 4683–90.
    PMID 16641261
    .
  • Ylinen, Laura M. J. (2005). "Differential Restriction of Human Immunodeficiency Virus Type 2 and Simian Immunodeficiency Virus SIVmac by TRIM5α Alleles". Journal of Virology. 79 (18). et al.: 11580–7.
    PMID 16140735
    .
  • Keckesova, Zuzana (2004). "The human and African green monkey TRIM5α genes encode Ref1 and Lv1 retroviral restriction factor activities". PNAS. 101 (29). et al.: 10780–10785.
    PMID 15249687
    .

Personal life

Kečkéšová has two children.[1]

References

  1. ^ a b c d e f g h i "Zuzana Kečkešová: Moju vedeckú kariéru naštartovalo štúdium v Londýne". vedanadosah.cvtisr.sk. 12 June 2018. Retrieved 2019-12-01.
  2. ^ a b "Jak uplatit rakovinu. Čeští miliardáři investují do výzkumu". Euro.cz (in Czech). 2019-02-09. Retrieved 2019-12-01.
  3. ^ a b "Strach z rakoviny může být inspirací, tvrdí bioložka Zuzana Kečkéšová". iDNES.cz. 2017-05-26. Retrieved 2019-12-01.
  4. ^ UCL (2018-04-12). "UCL Cancer Institute Seminar Series". UCL Cancer Institute. Retrieved 2019-12-01.
  5. ^ Prague, IOCB. "Zuzana Kečkéšová". IOCB Prague. Retrieved 2019-12-01.
  6. ^ EMBO. "EMBO Installation Grants support establishment of seven laboratories across Europe". EMBO. Retrieved 2019-12-01.
  7. ^ a b Prague, IOCB. "Private investor will support basic cancer-related research at IOCB Prague by € 1.75 million". IOCB Prague. Retrieved 2019-12-01.