List of JWH cannabinoids

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The John W. Huffman research group at Clemson University synthesized over 450 cannabinoids.[1][2][3][4] Some of those are:

Cannabinoids and their Ki values[a]
Name Class Ki / nM at CB1 Ki / nM at CB2 Selectivity Structure
JWH-004
Naphthoylindole
 48 ± 13 4 ± 1.5 CB2 (12x)
JWH-007[5]
Naphthoylindole
 9.5 ± 4.5 2.9 ± 2.6 CB2 (3.3x)
JWH-009
Naphthoylindole
 >10000 141 ± 14 CB2 (>70x)
JWH-011
Naphthoylindole
JWH-015[5] Naphthoylindole 164 ± 22 13.8 ± 4.6 CB2 (12x)
JWH-016 Naphthoylindole 22 ± 1.5 4.3 ± 1.6 CB2 (5.1x)
JWH-018[5] Naphthoylindole 9 ± 5 2.9 ± 2.6 CB2 (3.1x)
JWH-019 Naphthoylindole 9.8 ± 2 5.55 ± 2 CB2 (1.77x)
JWH-020 Naphthoylindole 128 ± 17 205 ± 20 CB1 (1.6x)
JWH-030
Naphthoylpyrrole
 87 ± 3 320 ± 127 CB1 (3.7x)
JWH-031 Naphthoylpyrrole 399 ± 109
JWH-032 Naphthoylpyrrole >10000 >10000 —
JWH-033 Naphthoylpyrrole 666 ± 77
JWH-036 Naphthoylpyrrole 309 ± 11
JWH-042[6] Naphthoylindole >10000 5050 ± 192 CB2
JWH-043[6] Naphthoylindole 1180 ± 44 964 ± 242 CB2 (1.2x)
JWH-044 Naphthoylpyrrole >10000 >10000 —
JWH-045 Naphthoylpyrrole >10000 >10000 —
JWH-046[6] Naphthoylindole 343 ± 38 16.3 ± 4.9 CB2 (21x)
JWH-047[6] Naphthoylindole 59 ± 3 3.47 ± 1.80 CB2 (17x)
JWH-048[6] Naphthoylindole 10.7 ± 1.0 0.49 ± 0.13 CB2 (22x)
JWH-049[6] Naphthoylindole 55.1 ± 17.0 32.3 ± 2.4 CB2 (1.7x)
JWH-050[6] Naphthoylindole 342 ± 6 526 ± 133 CB1 (1.5x)
JWH-051
Dibenzopyran
 1.20 0.03 CB2 (40x)
JWH-056[7] Dibenzopyran >10000 32 ± 9 CB2
JWH-057[8] Dibenzopyran 23 ± 7 2.9 ± 1.6 CB2 (8x)
JWH-065[7] Dibenzopyran 399 ± 76 10 ± 2 CB2 (40x)
JWH-070[6] Naphthoylindole >10000 >10000
JWH-071[6] Naphthoylindole 1340 ± 123 2940 ± 852 CB1 (2.2x)
JWH-072 Naphthoylindole 1050 ± 5.5 170 ± 54 CB2 (6x)
JWH-073 Naphthoylindole 8.9 ± 1.8 27 ± 12 CB1 (3x)
JWH-076[5] Naphthoylindole 214 ± 11 106 ± 46 CB2 (2x)
JWH-077[6] Naphthoylindole >10000 >10000
JWH-078[6] Naphthoylindole 817 ± 60 633 ± 116 CB2 (1.3x)
JWH-079[6] Naphthoylindole 63.0 ± 3.0 32.0 ± 6.0 CB2 (2x)
JWH-080[6] Naphthoylindole 8.9 ± 1.8 2.21 ± 1.30 CB2 (4x)
JWH-081[6] Naphthoylindole 1.2 ± 0.03 12.4 ± 2.2 CB1 (10x)
JWH-082[6] Naphthoylindole 5.3 ± 0.8 6.40 ± 0.94 CB1 (1.2x)
JWH-083[6] Naphthoylindole 106 ± 12 102 ± 50 —
THCP
)		 Dibenzopyran 22.0 ± 3.9
JWH-093[6] Naphthoylindole 40.7 ± 2.8 59.1 ± 10.5 CB1 (1.45x)
JWH-094[6] Naphthoylindole 476 ± 67 97.3 ± 2.7 CB2 (4.9x)
JWH-095[6] Naphthoylindole 140 ± 4.3 312 ± 83 CB1 (2.2x)
JWH-096[6] Naphthoylindole 33.7 ± 2.9 13.3 ± 5.6 CB2 (2.5x)
JWH-097[6] Naphthoylindole 455 ± 28 121 ± 15 CB2 (3.8x)
JWH-098[6] Naphthoylindole 4.5 ± 0.1 1.9 ± 0.3 CB2 (2.4x)
JWH-099[6] Naphthoylindole 35.3 ± 9.0 17.8 ± 2.9 CB2 (2x)
JWH-100[6] Naphthoylindole 381 ± 102 155 ± 74 CB2 (2.5x)
JWH-102[7] Dibenzopyran 7.9 ± 0.9 5.2 ± 2.0 CB2 (1.5x)
JWH-103[7] Dibenzopyran 28 ± 3 23 ± 7 CB2 (1.2x)
JWH-116[10] Naphthoylindole 52 ± 5
JWH-120[5] Naphthoylindole 1054 ± 31 6.1 ± 0.7 CB2 (173x)
JWH-122[10] Naphthoylindole 0.69 ± 0.05 1.2 ± 1.2 —
JWH-124 (Δ8-Parahexyl
)		 Dibenzopyran 41.0 ± 3.8
THCB
)		 Dibenzopyran 65.0 ± 13
JWH-133[7] Dibenzopyran 677 ± 132 3.4 ± 1.0 CB2 (200x)
JWH-138[11] Dibenzopyran 8.5 ± 1.4
JWH-139[12] Dibenzopyran 2290 ± 505 14 ± 10 CB2 (164x)
JWH-142[7] Dibenzopyran 529 ± 49 35 ± 14 CB2 (15x)
JWH-143[7] Dibenzopyran 924 ± 104 65 ± 8 CB2 (14x)
JWH-145[13] Naphthoylpyrrole 14 ± 2 6.4 ± 0.4 CB2 (2.2x)
JWH-146[13] Naphthoylpyrrole 21 ± 2 62 ± 5 CB2 (3.0x)
JWH-147[13] Naphthoylpyrrole 11 ± 1 7.1 ± 0.2 CB2 (1.5x)
JWH-148[5] Naphthoylindole 123 ± 8 14.0 ± 1.0 CB2 (8x)
JWH-149[5] Naphthoylindole 5.0 ± 2.1 0.73 ± 0.03 CB2 (6.8x)
JWH-150[13] Naphthoylpyrrole 60 ± 1 15 ± 2 CB2 (4x)
JWH-151[5] Naphthoylindole >10000 30 ± 1.1 CB2 (>333x)
JWH-153[5] Naphthoylindole 250 ± 24 11 ± 0.5 CB2 (23x)
JWH-156[13] Naphthoylpyrrole 404 ± 18 104 ± 18 CB2 (4x)
JWH-159[5] Naphthoylindole 45 ± 1 10.4 ± 1.4 CB2 (4.3x)
JWH-160[5] Naphthoylindole 1568 ± 201 441 ± 110 CB2 (3.6x)
JWH-161 Dibenzopyran hybrid 19.0
JWH-163[5] Naphthoylindole 2358 ± 215 138 ± 12 CB2 (17x)
JWH-164[5] Naphthoylindole 6.6 ± 0.7 6.9 ± 0.2 —
JWH-165[5] Naphthoylindole 204 ± 26 71 ± 8 CB2 (2.9x)
JWH-166[5] Naphthoylindole 44 ± 10 1.9 ± 0.08 CB2 (23x)
JWH-167 Phenylacetylindole 90 ± 17 159 ± 14 CB1 (1.77x)
JWH-171
 Hydrocarbon 51
JWH-175[10]
Naphthylmethylindole
 22 ± 2
JWH-176[10] Hydrocarbon 26 ± 4
JWH-180[5] Naphthoylindole 26 ± 2 9.6 ± 2.0 CB2 (2.7x)
JWH-181[5] Naphthoylindole 1.3 ± 0.1 0.62 ± 0.04 CB2 (2.1x)
JWH-182[5]
 Naphthoylindole 0.65 ± 0.03 1.1 ± 0.1 CB1 (1.7x)
JWH-184[10] Naphthylmethylindole 23 ± 6
JWH-185[10] Naphthylmethylindole 17 ± 3
JWH-186[14] Dibenzopyran 187 ± 23 5.6 ± 1.7 CB2 (33x)
JWH-187[14] Dibenzopyran 84 ± 16 3.4 ± 0.5 CB2 (25x)
JWH-188[14] Dibenzopyran 270 ± 58 18 ± 2 CB2 (15x)
JWH-189[5] Naphthoylindole 52 ± 2 12 ± 0.8 CB2 (4.3x)
JWH-190[14] Dibenzopyran 8.8 ± 1.4 1.6 ± 0.03 CB2 (5.5x)
JWH-191[14] Dibenzopyran 1.8 ± 0.3 0.52 ± 0.03 CB2 (3.5x)
JWH-192[10] Naphthylmethylindole 41 ± 13
JWH-193[10] Naphthoylindole 6 ± 1
JWH-194[10] Naphthylmethylindole 127 ± 19
JWH-195[10] Naphthylmethylindole 113 ± 28
JWH-196[10] Naphthylmethylindole 151 ± 18
JWH-197[10] Naphthylmethylindole 323 ± 98
JWH-198[10] Naphthoylindole 10 ± 2
JWH-199[10] Naphthylmethylindole 20 ± 2
JWH-200[10] Naphthoylindole 42 ± 5
JWH-201[15] Phenylacetylindole 1064 ± 21 444 ± 14 CB2 (2.4x)
JWH-202[15] Phenylacetylindole 1678 ± 63 645 ± 6 CB2 (2.6x)
JWH-203[15] Phenylacetylindole 8.0 ± 0.9 7.0 ± 1.3 —
JWH-204[15] Phenylacetylindole 13 ± 1 25 ± 1 CB1 (1.9x)
JWH-205[15] Phenylacetylindole 124 ± 23 180 ± 9 CB1 (1.45x)
JWH-206[15] Phenylacetylindole 389 ± 25 498 ± 37 CB1 (1.28x)
JWH-207[15] Phenylacetylindole 1598 ± 134 3723 ± 10 CB1 (2.33x)
JWH-208[15] Phenylacetylindole 179 ± 7 570 ± 127 CB1 (3.18x)
JWH-209[15] Phenylacetylindole 746 ± 49 1353 ± 270 CB1 (1.81x)
JWH-210[5] Naphthoylindole 0.46 ± 0.03 0.69 ± 0.01 CB1 (1.5x)
JWH-211[5] Naphthoylindole 70 ± 0.8 12 ± 0.8 CB2 (5.8x)
JWH-212[5] Naphthoylindole 33 ± 0.9 10 ± 1.2 CB2 (3.3x)
JWH-213[5] Naphthoylindole 1.5 ± 0.2 0.42 ± 0.05 CB2 (3.6x)
JWH-215[14] Dibenzopyran 1008 ± 117 85 ± 21 CB2 (12x)
JWH-216[14] Dibenzopyran 1856 ± 148 333 ± 104 CB2 (5.6x)
JWH-217[14] Dibenzopyran >10000 1404 ± 66 CB2 (>7x)
JWH-220 Hydrocarbon 19
JWH-224[14] Dibenzopyran 347 ± 34 28 ± 1 CB2 (12.3x)
JWH-225[14] Dibenzopyran >10000 325 ± 70 CB2 (>31x)
JWH-226[14] Dibenzopyran 4001 ± 282 43 ± 3 CB2 (93x)
JWH-227[14] Dibenzopyran 40 ± 6 4.4 ± 0.3 CB2 (9x)
JWH-229[16] Dibenzopyran 3134 ± 110 18 ± 2 CB2 (174x)
JWH-230[14] Dibenzopyran 15 ± 3 1.4 ± 0.12 CB2 (10.7x)
JWH-233[14] Dibenzopyran 14 ± 3 1.0 ± 0.3 CB2 (14x)
JWH-234[5] Naphthoylindole 8.4 ± 1.8 3.8 ± 0.6 CB2 (2.2x)
JWH-235[5] Naphthoylindole 338 ± 34 123 ± 34 CB2 (2.7x)
JWH-236[5] Naphthoylindole 1351 ± 204 240 ± 63 CB2 (5.6x)
JWH-237[15] Phenylacetylindole 38 ± 10 106 ± 2 CB1 (2.8x)
JWH-239[5] Naphthoylindole 342 ± 20 52 ± 6 CB2 (6.6x)
JWH-240[5] Naphthoylindole 14 ± 1 7.2 ± 1.3 CB2 (1.9x)
JWH-241[5] Naphthoylindole 147 ± 20 49 ± 7 CB2 (3.0x)
JWH-242[5] Naphthoylindole 42 ± 9 6.5 ± 0.3 CB2 (6.5x)
JWH-243[13] Naphthoylpyrrole 285 ± 40 41 ± 3 CB2 (6.95x)
JWH-244[13] Naphthoylpyrrole 130 ± 6 18 ± 1 CB2 (7.22x)
JWH-245[13] Naphthoylpyrrole 276 ± 4 25 ± 2 CB2 (11x)
JWH-246[13] Naphthoylpyrrole 70 ± 4 16 ± 1 CB2 (4.38x)
JWH-247[14] Dibenzopyran 427 ± 31 99 ± 4 CB2 (4.3x)
JWH-248[15] Phenylacetylindole 1028 ± 39 657 ± 19 CB2 (1.56x)
JWH-249[15] Phenylacetylindole 8.4 ± 1.8 20 ± 2 CB1 (2.38x)
JWH-250[15] Phenylacetylindole 11 ± 2 33 ± 2 CB1 (3x)
JWH-251[15] Phenylacetylindole 29 ± 3 146 ± 36 CB2 (5x)
JWH-252[15] Phenylacetylindole 23 ± 3 19 ± 1 CB2 (1.2x)
JWH-253[15] Phenylacetylindole 62 ± 10 84 ± 12 CB1 (1.35x)
JWH-254[14] Dibenzopyran 4724 ± 509 319 ± 16 CB2 (14.8x)
JWH-256[14] Dibenzopyran 4300 ± 888 97 ± 18 CB2 (44x)
JWH-258[5] Naphthoylindole 4.6 ± 0.6 10.5 ± 1.3 CB1 (2.3x)
JWH-259[5] Naphthoylindole 220 ± 29 74 ± 7 CB2 (3.0x)
JWH-260[5] Naphthoylindole 29 ± 0.4 25 ± 1.9 CB2 (1.2x)
JWH-261[5] Naphthoylindole 767 ± 105 221 ± 14 CB2 (3.5x)
JWH-262[5] Naphthoylindole 28 ± 3 5.6 ± 0.7 CB2 (5.0x)
JWH-265[5] Naphthoylindole 3788 ± 323 80 ± 13 CB2 (47x)
JWH-266[5] Naphthoylindole >10000 455 ± 55 CB2 (>22x)
JWH-267[5] Naphthoylindole 381 ± 16 7.2 ± 0.14 CB2 (53x)
JWH-268[5] Naphthoylindole 1379 ± 193 40 ± 0.6 CB2 (34x)
JWH-277[14] Dibenzopyran 3905 ± 91 589 ± 65 CB2 (6.6x)
JWH-278[14] Dibenzopyran 906 ± 80 69 ± 6 CB2 (13x)
JWH-292[13] Naphthoylpyrrole 29 ± 1 20 ± 1 CB2 (1.45x)
JWH-293[13] Naphthoylpyrrole 100 ± 5 41 ± 4 CB2 (2.44x)
JWH-298[14] Dibenzopyran 812 ± 67 198 ± 23 CB2 (4.1x)
JWH-299[14] Dibenzopyran 415 ± 50 30 ± 2 CB2 (13.8x)
JWH-300[12] Dibenzopyran 118 ± 16 5.3 ± 0.1 CB2 (22x)
JWH-301[14] Dibenzopyran 295 ± 64 48 ± 4 CB2 (6.1x)
JWH-302[15] Phenylacetylindole 17 ± 2 89 ± 15 CB1 (5.26x)
JWH-303[15] Phenylacetylindole 117 ± 10 138 ± 12 CB1 (1.18x)
JWH-304[15] Phenylacetylindole 3363 ± 332 2679 ± 688 CB2 (1.26x)
JWH-305[15] Phenylacetylindole 15 ± 1.8 29 ± 5 CB1 (1.93x)
JWH-306[15] Phenylacetylindole 25 ± 1 82 ± 11 CB1 (3.28x)
JWH-307[13] Naphthoylpyrrole 7.7 ± 1.8 3.3 ± 0.2 CB2 (2.33x)
JWH-308[13] Naphthoylpyrrole 41 ± 1 33 ± 2 CB2 (1.24x)
JWH-309[13] Naphthoylpyrrole 41 ± 3 49 ± 7 CB1 (1.20x)
JWH-310[14] Dibenzopyran 1059 ± 51 36 ± 3 CB2 (29x)
JWH-311[15] Phenylacetylindole 23 ± 2 39 ± 3 CB1 (1.70x)
JWH-312[15] Phenylacetylindole 72 ± 7 91 ± 20 CB1 (1.26x)
JWH-313[15] Phenylacetylindole 422 ± 19 365 ± 92 CB2 (1.16x)
JWH-314[15] Phenylacetylindole 39 ± 2 76 ± 4 CB1 (1.95x)
JWH-315[15] Phenylacetylindole 430 ± 24 182 ± 23 CB2 (3.36x)
JWH-316[15] Phenylacetylindole 2862 ± 670 781 ± 105 CB2 (3.66x)
JWH-336[12] Dibenzopyran 4589 ± 367 153 ± 15 CB2 (30x)
JWH-338[14] Dibenzopyran >10000 111 ± 16 CB2 (>90x)
JWH-339[14] Dibenzopyran >10000 2317 ± 93 CB2 (>4.3x)
JWH-340[14] Dibenzopyran 135 ± 6 30 ± 1 CB2 (4.5x)
JWH-341[14] Dibenzopyran 100 ± 8 10 ± 0.1 CB2 (10x)
JWH-346[13] Naphthoylpyrrole 67 ± 6 39 ± 2 CB2 (1.72x)
JWH-347[13] Naphthoylpyrrole 333 ± 17 169 ± 17 CB2 (1.97x)
JWH-348[13] Naphthoylpyrrole 218 ± 19 53 ± 1 CB2 (4.11x)
JWH-349[14] Dibenzopyran 376 ± 1 38 ± 4 CB2 (9.9x)
JWH-350[12] Dibenzopyran 395 ± 50 12 ± 1 CB2 (33x)
JWH-351[14] Dibenzopyran >10000 295 ± 3 CB2 (>34x)
JWH-352[14] Dibenzopyran >10000 47 ± 2 CB2 (>213x)
JWH-353[14] Dibenzopyran 1493 ± 10 31 ± 1 CB2 (48x)
JWH-354[14] Dibenzopyran 1961 ± 21 241 ± 14 CB2 (8.1x)
JWH-355[14] Dibenzopyran 2162 ± 220 108 ± 17 CB2 (20x)
JWH-356[14] Dibenzopyran 5837 ± 701 108 ± 17 CB2 (54x)
JWH-357[14] Dibenzopyran 647 ± 78 185 ± 4 CB2 (3.5x)
JWH-358[14] Dibenzopyran 1243 ± 266 52 ± 3 CB2 (24x)
JWH-359 Dibenzopyran 2918 ± 450 13.0 ± 0.2 CB2 (220x)
JWH-360[14] Dibenzopyran 2449 ± 606 160 ± 8 CB2 (15x)
JWH-361[14] Dibenzopyran 63 ± 3 2.7 ± 0.1 CB2 (23x)
JWH-362[14] Dibenzopyran 127 ± 8 34 ± 5 CB2 (3.7x)
JWH-363[13] Naphthoylpyrrole 245 ± 5 71 ± 1 CB2 (3.45x)
JWH-364[13] Naphthoylpyrrole 34 ± 3 29 ± 1 CB2 (1.17x)
JWH-365[13] Naphthoylpyrrole 17 ± 1 3.4 ± 0.2 CB2 (5.0x)
JWH-366[13] Naphthoylpyrrole 191 ± 12 24 ± 1 CB2 (7.96x)
JWH-367[13] Naphthoylpyrrole 53 ± 2 23 ± 1 CB2 (2.30x)
JWH-368[13] Naphthoylpyrrole 16 ± 1 9.1 ± 0.7 CB2 (1.76x)
JWH-369[13] Naphthoylpyrrole 7.9 ± 0.4 5.2 ± 0.3 CB2 (1.52x)
JWH-370[13] Naphthoylpyrrole 5.6 ± 0.4 4.0 ± 0.5 CB2 (1.40x)
JWH-371[13] Naphthoylpyrrole 42 ± 1 64 ± 2 CB1 (1.52x)
JWH-372[13] Naphthoylpyrrole 77 ± 2 8.2 ± 0.2 CB1 (9.39x)
JWH-373[13] Naphthoylpyrrole 60 ± 3 69 ± 2 CB1 (1.15x)
JWH-387[17] Naphthoylindole 1.2 ± 0.1 1.1 ± 0.1 —
JWH-398[18] Naphthoylindole 2.3 ± 0.1 2.8 ± 0.2 CB1 (1.22x)
JWH-416[17] Naphthoylindole 73 ± 10 3.3 ± 0.1 CB2 (22x)
JWH-417[17] Naphthoylindole 522 ± 58 13 ± 0.2 CB2 (40x)
JWH-422[17] Naphthoylindole 501 ± 48 20 ± 0.4 CB2 (25x)
JWH-423[17] Naphthoylindole 140 ± 10 6.6 ± 0.2 CB2 (21x)
JWH-424[17] Naphthoylindole 21 ± 3.4 5.4 ± 0.2 CB2 (3.9x)
JWH-425[17] Naphthoylindole 54 ± 11 10 ± 0.4 CB2 (5.4x)


See also

Notes

  1. cannabinoid receptor type 2
    (CB2).

References

  1. PMID 18473928
    .
  2. PMID 24071522
    .
  3. PMID 27753007
    .
  4. PMID 29980914
    .
  5. ^
    PMID 15582455
    .
  6. ^
    PMID 10940540
    .
  7. ^
    PMID 10658595
    .
  8. PMID 8831752
    .
  9. PMID 27398024
  10. ^
    S2CID 29107765
    .
  11. PMID 10454479
  12. ^
    S2CID 8259002
    .
  13. ^
    PMID 16889960
    .
  14. ^
    PMID 18289088
    .
  15. ^
    PMID 16005223
    .
  16. PMID 12413866
    .
  17. ^
    PMID 22341572
    .
  18. ISBN 978-1-58829-712-9
    .
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