Acetalated dextran

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Acetalated dextran

Names
IUPAC name varies
Other names Ac-DEX, Ace-DEX, modified dextran
Identifiers
ChemSpider	none
Properties
Molar mass	varies
Appearance	white powder
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Acetalated dextran is a biodegradable polymer based on

Acetalated dextran was first reported in 2008 out of the lab of Jean Fréchet at the University of California, Berkeley in the College of Chemistry.^[2][3] This version of acetalated dextran, often abbreviated Ac-DEX, has dextran and exceedingly low levels of acetone and methanol as degradation products. In 2012, in the laboratory of Kristy Ainslie, at Ohio State University in the College of Pharmacy, polymer synthesis was modified to release ethanol in place of methanol upon degradation.^[4] The ethanol producing version of acetalated dextran is often abbreviated Ace-DEX.

Properties

During the synthesis of acetalated dextran both acyclic and cyclic acetals are formed. The acyclic acetals degrade into an

Ac-DEX has also been shown the allow proteins to be stored outside the cold chain.^[10]

References