Cold chain
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Cold chain is a set of rules and procedures that ensure the systematic coordination of activities for ensuring temperature-control of goods while in storage and transit. The objective of a cold chain is to preserve the integrity and quality of goods such as pharmaceutical products or perishable good from production to consumption. [1] [2] Cold chain management earned its name as a "chain" because it involves linking a set of storage locations and special transport equipment, required for ensuring that temperature conditions for goods are met, while they are in storage or in transit from production to consumption, akin to the interconnected links of a physical chain.
An unbroken cold chain is an uninterrupted sequence of refrigerated production, storage and distribution activities, along with associated equipment and logistics, which maintain a desired low-temperature interval to keep the safety and quality of perishable or sensitive products, such as foods and medicines.
History
Mobile refrigeration with ice from the ice trade began with reefer ships and refrigerator cars (iceboxes on wheels) in the mid-19th century.[8] The term cold chain was first used in 1908. The first effective cold store in the UK opened in 1882 at St Katharine Docks.[9] It could hold 59,000 carcasses, and by 1911 cold storage capacity in London had reached 2.84 million carcasses.[9] By 1930 about a thousand refrigerated meat containers were in use which could be switched from road to railway.[9]
Mobile mechanical refrigeration was invented by
This technology has been frequently in use since the 1950s, when it was most often used for preserving animal-based cells or tissue. As medical breakthroughs, such as in cancer treatment, have taken place, the demand for cold chain systems has grown. The COVID-19 pandemic and its associated vaccinations, have caused vastly increased need.[14]
Uses
Cold chains are common in the food and
Produce
Unique to fresh produce cargoes, the cold chain requires to additionally maintain product specific environment parameters[4] which include air quality levels (carbon dioxide, oxygen, humidity and others).[citation needed]
Vaccines
The cold chain is used in the supply of
For vaccines, there are different types of cold chains. There is an ultralow, or deep freeze, cold chain for vaccines that require -70 degrees C, such as the Ebola and
In 2020, during the COVID-19 pandemic, vaccines being developed may need ultracold storage and transportation temperatures as cold as −70 °C (−94 °F), requiring what has been referred to as a "colder chain" infrastructure.[18] This creates some issues of distribution for the Pfizer vaccine. It is estimated that only 25 to 30 countries in the world have the infrastructure for the required ultracold cold chain.[17]
Validation
The cold chain distribution process is an extension of the good manufacturing practice (GMP) environment that all drugs and biological products are required to follow, and are enforced by the various health regulatory bodies. As such, the distribution process must be validated to ensure that there is no negative impact to the safety, efficacy or quality of the drug substance. The GMP environment requires that all processes that might impact the safety, efficacy or quality of the drug substance must be validated, including storage and distribution of the drug substance.[18][3]
A cold chain can be managed by a
Role of warehousing in integrated cold chain management
It is important to understand cold chain management as an integrated system of individual components that come together a seamless system for transportation of goods that can maintain the required temperature range during the period the shipment is in the system. Warehouses at both ends of the transport as well as those in transit are important for maintaining the integrity of the chain. The reason why source and destination warehouses need equal importance is because preparing the cold chain packaging for transport is a very important dimension and is as important as conditioning the product itself for transport.[22]
Regulatory guideless emphasise of strong managerial oversight for the quality systems that ensure integrity of the chain.
See also
- Bacterial growth
- Pharmaceutical distribution
- Dry ice
- Phase-change material
- Frank Vale, cold storage pioneer
- HACCP
- Insulated shipping container
- Packaging
- Shelf life
- Temperature control
- Temperature data logger
- Time temperature indicator
- Thermal decomposition
- Thermal insulation
- Tolerance (engineering)
- Transportation management system
- United States Pharmacopeia
- Vaccine storage
- Validation (drug manufacture)
- Verification and validation
- ULT freezer
Sources
This article incorporates text from a free content work. Licensed under CC BY-SA 3.0 (license statement/permission). Text taken from The State of Food and Agriculture 2019. Moving forward on food loss and waste reduction, In brief, 24, FAO, FAO.
References
- ^ "Cold Chain - PAHO/WHO | Pan American Health Organization".
- ^ https://www.who.int/docs/default-source/searo/india/publications/immunization-handbook-107-198-part2.pdf
- ^ a b "The Vaccine Cold Chain" (PDF). www.who.int. WHO. Retrieved 19 December 2020.
- ^ a b Kohli, Pawanexh. "Fruits and Vegetables Post-Harvest Care: The Basics" (PDF). CrossTree techno-visors. Retrieved 6 April 2009.[dead link]
- ^ Gyesley, S. W. (1991). "Total Systems Approach to Predict Shelf Life of Packaged Foods". ASTM STP 1113-EB.
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(help) - ^ Lou Smyrlis (19 September 2013). "CN's Claude Mongeau preaches 'eco-system of collaboration' at Port Days" Archived 21 September 2013 at the Wayback Machine, Canadian Transportation Logistics, Retrieved 20 September 2013
- ^ The State of Food and Agriculture 2019. Moving forward on food loss and waste reduction, In brief. Rome: FAO. 2019. p. 12.
- ^ "FRIDGE SPACE - Bibliothèque et Archives Canada".
- ^ ISBN 978-0-226-69710-9.
- ^ a b "Frederick McKinley Jones". Minnesota Science and Technology Hall of Fame. Minnesota High Tech Association / Science Museum of Minnesota. Retrieved 11 February 2010.
- ^ ISBN 978-1-57859-424-5.
- ^ Eight Black American Inventors by Robert C. Hayden Addison-Wesley, 1972; pp. 46- 50.
- ^ "Air Conditioning and Refrigeration History - part 4 - Greatest Engineering Achievements of the Twentieth Century". www.greatachievements.org. Archived from the original on 3 December 2016. Retrieved 24 April 2018.
- ^ Kelly, Kate (15 December 2020). "Critical to Vaccines, Cold Storage Is Wall Street's Shiny New Thing". The New York Times. Retrieved 20 December 2020.
- S2CID 245490703.
- ^ "Office of Medical History". history.amedd.army.mil. Archived from the original on 16 February 2017. Retrieved 24 April 2018.
- ^ a b Fischetti, Mark (19 November 2020). "The COVID Cold Chain: How a Vaccine Will Get to You". www.scientificamerican.com. Scientific American. Archived from the original on 19 December 2020. Retrieved 20 December 2020.
- ^ a b Derek Lowe (31 August 2020). "Cold Chain (And Colder Chain) Distribution". Science Translational Medicine. Retrieved 5 September 2020.
- S2CID 108566613.
- ^ Meyers, T (June 2007). "RFID Shelf-life Monitoring Helps Resolve Disputes". RFID Journal. Archived from the original on 30 June 2009.
- ^ "Cold Chain Temperature Monitoring – Absolute Automation Blog". absoluteautomation.com. 27 May 2016. Archived from the original on 24 April 2018. Retrieved 24 April 2018.
- ^ Yurtseven, C., Ekren, B. Y., & Toy, A. O. (2022). An Overview of Warehouse Operations for Cold Chain. In Industrial Engineering in the Internet-of-Things World: Selected Papers from the Virtual Global Joint Conference on Industrial Engineering and Its Application Areas, GJCIE 2020, August 14–15, 2020 (pp. 161-175). Springer International Publishing. https://link.springer.com/chapter/10.1007/978-3-030-76724-2_13
- ^ Bishara, R. H. (2006). Cold chain management–an essential component of the global pharmaceutical supply chain. American Pharmaceutical Review, 9(1), 105-109. https://intelsius.com/wp-content/uploads/2011/10/Pharma-Cold-Chain-Bishara_APR.pdf
- ^ Who, W. H. O. (2010). Good Distribution Practices for Pharmaceutical Products. Technical Report Series. World Health Organization, Annex, 5. https://www.cls.co.at/media/files/who_gdp_tr957_annex5_cls_co_at.pdf
- ^ "TRS 1025 - Annex 7: Good storage and distribution practices for medical products".
Further reading
- Brecht, Jeffrey K.; Sargent, Steven A.; Brecht, Patrick E.; Saenz, Jorge; Rodowick, Leonard (2019). Protecting Perishable Foods During Transport by Truck and Rail. Supersedes USDA Handbook 669 of 1995. Document HS1328 of the Horticultural Sciences Department, Institute of Food and Agricultural Sciences, University of Florida. Retrieved 9 May 2023.
- Brian Lassen, "Is livestock production prepared for an electrically paralysed world?" J. Sci. Food Agric. 2013;93(1):2–4, Explains the vulnerability of the cold chain from electricity dependence.
- Manual on the Management, Maintenance and Use of Blood Cold Chain Equipment, ISBN 92-4-154673-5
- Pawanexh Kohli, "Fruits and Vegetables Post-Harvest Care: The Basics", Explains why the cold chain is required for fruits and vegetables.
- Clive, D., Cold and Chilled Storage Technology, 1997, ISBN 0-7514-0391-1
- EN 12830:1999 Temperature recorders for the transport, storage and distribution of chilled, frozen and deep-frozen/quick-frozen food and ice cream
- Ray Cowland, Developing ISTA Cold Chain Environmental Standards, 2007.
- Rees, Jonathan (2013). "Chapter 1: Inventing the cold chain". Refrigeration Nation: A History of Ice, Appliances, and Enterprise in America. Studies in Industry and Society. Johns Hopkins University Press. pp. 11–30. ISBN 9781421411064.
- Nordic Cold Chain Solutions, Manufacturer of temperature-controlled packaging, nordiccoldchain.com-->