Adrenochrome

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This article is about the chemical compound. For the conspiracy theory about Satanic child sacrifice, see QAnon.
For the Sisters of Mercy song, see Some Girls Wander by Mistake.

Adrenochrome
Structural formula of adrenochrome
Ball-and-stick model of the adrenochrome molecule
Names
IUPAC name
3-Hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione
Other names
Adraxone; Pink adrenaline
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
 100.000.176 Edit this at Wikidata
EC Number
  • (
    racemic
    ): 200-192-8
UNII
  • InChI=1S/C9H9NO3/c1-10-4-9(13)5-2-7(11)8(12)3-6(5)10/h2-3,9,13H,4H2,1H3 checkY
    Key: RPHLQSHHTJORHI-UHFFFAOYSA-N checkY
  • (
    racemic
    ): InChI=1/C9H9NO3/c1-10-4-9(13)5-2-7(11)8(12)3-6(5)10/h2-3,9,13H,4H2,1H3
    Key: RPHLQSHHTJORHI-UHFFFAOYAD
  • (
    racemic
    ): O=C1\C=C2/C(=C\C1=O)N(CC2O)C
Properties
C9H9NO3
Molar mass 179.175 g·mol−1
Appearance deep-violet[1]
Density 3.264 g/cm3
Boiling point 115–120 °C (239–248 °F; 388–393 K) (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Adrenochrome is a

hemostatic
medication.

Despite this compound's name, it is unrelated to the element chromium; instead, the ‑chrome suffix indicates a relationship to color, as pure adrenochrome has a deep violet coloration.[1]

Chemistry

The oxidation reaction that converts adrenaline into adrenochrome occurs both in vivo and in vitro. Silver oxide (Ag2O) was among the first reagents employed for this,[2] but a variety of other oxidising agents have been used successfully.[3] In solution, adrenochrome is pink and further oxidation of the compound causes it to polymerize into brown or black melanin compounds.[4]

History

An adrenochrome ampoule

Several small-scale studies (involving 15 or fewer test subjects) conducted in the 1950s and 1960s reported that adrenochrome triggered

psychotic reactions such as thought disorder and derealization.[5]

In 1954, researchers

psychotomimetic substance and may play a role in schizophrenia and other mental illnesses.[6]

In what Hoffer called the "adrenochrome hypothesis",

niacin could cure schizophrenia by reducing brain adrenochrome.[8][9]

The treatment of schizophrenia with such potent anti-oxidants is highly contested. In 1973, the American Psychiatric Association reported methodological flaws in Hoffer's work on niacin as a schizophrenia treatment and referred to follow-up studies that did not confirm any benefits of the treatment.[10] Multiple additional studies in the United States,[11] Canada,[12] and Australia[13] similarly failed to find benefits of megavitamin therapy to treat schizophrenia.

The adrenochrome theory of schizophrenia waned, despite some evidence that it may be

psychotomimetic, as adrenochrome was not detectable in people with schizophrenia.[citation needed
]

In the early 2000s, interest was renewed by the discovery that adrenochrome may be produced normally as an intermediate in the formation of

glutathione-S-transferase. Some studies have found genetic defects in the gene for this enzyme.[14]

Adrenochrome is also believed to have cardiotoxic properties.[15][16]

In popular culture

  • In his 1954 book The Doors of Perception, Aldous Huxley mentioned the discovery and the alleged effects of adrenochrome, which he likened to the symptoms of mescaline intoxication, although he had never consumed it.[17]
  • Anthony Burgess mentions adrenochrome as "drencrom" at the beginning of his 1962 novel A Clockwork Orange. The protagonist and his friends are drinking drug-laced milk: "They had no license for selling liquor, but there was no law yet against prodding some of the new veshches which they used to put into the old moloko, so you could peet it with vellocet or synthemesc or drencrom or one or two other veshches [...]"[17]
  • Hunter S. Thompson mentioned adrenochrome in his 1971 book Fear and Loathing in Las Vegas.[18] This is the likely origin of current myths surrounding this compound, because a character states that "There's only one source for this stuff ... the adrenaline glands from a living human body. It's no good if you get it out of a corpse." The adrenochrome scene also appears in the novel's film adaptation.[17] In the DVD commentary, director Terry Gilliam admits that his and Thompson's portrayal is a fictional exaggeration. Gilliam insists that the drug is entirely fictional and seems unaware of the existence of a substance with the same name. Hunter S. Thompson also mentions adrenochrome in his book Fear and Loathing on the Campaign Trail '72. In the footnotes in chapter April, page 140, he says: "It was sometime after midnight in a ratty hotel room and my memory of the conversation is hazy, due to massive ingestion of booze, fatback, and forty cc's of adrenochrome."
  • Adrenochrome is a subject of several
    Satanic ritual abuse stories.[22] The theories commonly state that a cabal of Satanists rape and murder children, and "harvest" adrenochrome from their victims' blood as a drug[23][24] or as an elixir of youth.[25] In reality, adrenochrome is synthesized by biotechnology companies, solely for research purposes, and has no medical uses.[26][27][28]

References

  1. ^
    doi:10.1139/v58-124
    .
  2. doi:10.1002/recl.19420610904
    .
  3. doi:10.1021/cr50026a001
    .
  4. ISBN 978-1-4832-6169-0
    .
  5. ^
    S2CID 37594882
    .
  6. S2CID 42531852
    .
  7. S2CID 41468628. Archived
    from the original on 20 February 2024. Retrieved 15 March 2024.
  8. OL 35255701M. Retrieved 15 March 2024 – via Internet Archive
    .
  9. ^ Hoffer A (1994). "Schizophrenia: An Evolutionary Defense Against Severe Stress" (PDF). Journal of Orthomolecular Medicine. 9 (4): 205–2221.
  10. ^ Lipton MA, Ban TA, Kane FJ, Levine J, Mosher LR, Wittenborn R (1973). "Task Force Report on Megavitamin and Orthomolecular Therapy in Psychiatry" (PDF). American Psychiatric Association. Archived from the original (PDF) on 23 February 2021. Retrieved 7 September 2020.
  11. PMID 4569673
    .
  12. doi:10.1093/schbul/1.3.5
    .
  13. S2CID 38857700
    .
  14. ISBN 978-0-12-366860-8
    .
  15. PMID 2665188
    .
  16. S2CID 27865845
    .
  17. ^ a b c Adams J (7 April 2020). "The truth about adrenochrome". The Spinoff. Retrieved 28 June 2020.
  18. ^ Friedberg B. "The Dark Virality of a Hollywood Blood-Harvesting Conspiracy". Wired. Retrieved 21 February 2021.
  19. ^ "Fear and adrenochrome". Spectator USA. 4 May 2020. Archived from the original on 20 September 2020. Retrieved 23 May 2020.
  20. ^ "How Facebook connects 'pizzagate' conspiracy theorists". NBC News. February 2019. Retrieved 23 May 2020.
  21. ^ Dunning B (20 October 2020). "Skeptoid #750: How to Extract Adrenochrome from Children". Skeptoid. Retrieved 20 October 2020.
  22. ^ Kantrowitz L (29 September 2020). "QAnon, Blood Libel, and the Satanic Panic". The New Republic. Retrieved 8 May 2021.
  23. ^ Friedberg B (31 July 2020). "The Dark Virality of a Hollywood Blood-Harvesting Conspiracy". Wired. Retrieved 16 February 2022.
  24. ^ Hitt T (14 August 2020). "How QAnon Became Obsessed With 'Adrenochrome,' an Imaginary Drug Hollywood Is 'Harvesting' from Kids". The Daily Beast. Retrieved 27 January 2021.
  25. ^ "QAnon: A Glossary". Anti-Defamation League. 21 January 2021. Retrieved 15 February 2022.
  26. ^ Walker-Journey, Jennifer (14 April 2021). "Untangling the Medical Misinformation Around Adrenochrome". HowStuffWorks. Archived from the original on 14 April 2021. Retrieved 25 October 2022.
  27. doi:10.1021/ja01129a531. Archived
    from the original on 25 October 2022. Retrieved 25 October 2022.
  28. ^ "Method of synthesizing adrenochrome monoaminoguanidine". Google Patents. 1965. Archived from the original on 16 October 2021. Retrieved 25 October 2022.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Adrenochrome&oldid=1216042378"