Alfred L. Goldberg

Alfred Lewis Goldberg (September 3, 1942 – April 18, 2023) was an American

Early life and career

Goldberg was born in

From 1970, Goldberg was married to Joan Helpern Goldberg, a physician (hematologist). They had two children, Aaron Goldberg, a well-known jazz pianist, and Julie B. Goldberg, a software engineer.

Alfred L. Goldberg died on April 18, 2023, at the age of 80.^[40]

Professional honors

• Member of the
  American Academy of Arts & Sciences (2005)^[41]
• Member of the National Academy of Medicine (2009)^[42]
• Member of the National Academy of Sciences (2015)^[42]
• Fellow of the American Physiological Society (2015)^[43]
• Honorary DSc. Degree Watson School of Biology (Cold Spring Harbor Laboratory) (2009)^[44]
• Honorary DSc. Degree Maastricht University (Netherlands) (2011)
• Honorary DSc. Degree University of Barcelona (Spain) (2014)^[45]
• Novartis-Drew University Award in Biochemical Science (with T. Maniatis & A. Varshavsky) (1998)
• Knobil Prize for Medical Research (Univ Texas School of Medicine, 2007)
• Gabbay Award for Biotechnology & Medicine (Brandeis University, 2008)^[46]
• Warren Alpert Foundation Prize, Harvard Medical School (with J. Adams, K. Anderson, P. Richardson) (2012)^[47]
• Ernest Beutler Prize for Basic Science, American Society of Hematology (2015)^[48]
• Passano Prize for Medical Research (Johns Hopkins University, 2021)^[49]
• Symposium honoring Dr. Goldberg’s “Pioneering contributions to muscle metabolism”, Cachexia Society (Chicago, 2004)
• Symposium on “Protein Modification and Degradation” honoring Dr. Goldberg’s 65th Birthday,
  Chinese Academy of Medical Sciences
  (Beijing, 2007)

Prize Lectureships

• Francis McNaughton Lecture, McGill University-Montreal-Neurological Institute (1997)
• Bathsheva Rothchild Memorial Lecture,
  Israel Academy of Sciences
  (1998)
• Leonardo da Vinci Lecture, San Raffaelle Med School, Milan, Italy (2002)
• Fred Fay Memorial Lecture,
  University of Massachusetts Medical School
  (2003)
• Severo Ochoa Prize Lecture, New York University (2004)
• Nobel Forum Lecture, Karolinska Institute (Sweden) (2005)
• Centennial Lecture, Biochemical Society, England (2006)
• Cristofalo Prize Lecture, Aging Institute (University of Pennsylvania) (2015)
• Benevuto Prize Lecture, MD Anderson Cancer Center Univ. Texas Medical Center (Houston) (2019)

Influential publications

1. Goldberg AL. Degradation of abnormal proteins in Escherichia coli (protein breakdown-protein structure-mistranslation-amino acid analogs-puromycin). Proc Natl Acad Sci U S A. 1972 Feb;69(2):422-6. PubMed PMID 4551144; PubMed Central PMCID: PMC426471.
2. Prouty WF, Goldberg AL. Fate of abnormal proteins in E. coli accumulation in intracellular granules before catabolism. Nat New Biol. 1972 Nov 29;240(100):147-50. PubMed PMID 4565695.
3. Goldberg AL, St John AC. Intracellular protein degradation in mammalian and bacterial cells: Part 2. Annu Rev Biochem. 1976;45:747-803. PubMed PMID 786161.
4. Goldberg AL and Dice JF. Intracellular protein degradation in mammalian and bacterial cells. Ann Rev Biochem 1974; 43: 835-869. PubMed PMID 4604628.
5. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature. 2003 Dec 18;426(6968):895-9. PubMed PMID 14685250.
6. Etlinger JD, Goldberg AL. A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes. Proc Natl Acad Sci U S A. 1977 Jan;74(1):54-8. PubMed PMID 264694; PubMed Central PMCID: PMC393195.
7. Chung CH, Goldberg AL. The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease, protease La. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4931-5. PubMed PMID 6458037; PubMed Central PMCID: PMC320299.
8. Tanaka K, Waxman L and Goldberg AL. ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin. J Cell Biol 1983; 96: 1580-1585.
9. Goff SA and Goldberg AL. Production of abnormal proteins in E. coli stimulates transcription of lon and other heat-shock genes. Cell 1985; 41: 587-595. PubMed PMID 3886165.
10. Waxman L, Fagan JM, Goldberg AL. Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates. J Biol Chem. 1987 Feb 25;262(6):2451-7. PubMed PMID 3029081.
11. Hwang BJ, Park WJ, Chung CH, Goldberg AL. Escherichia coli contains a soluble ATP-dependent protease (Ti) distinct from protease La. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5550-4. PubMed PMID 3303028; PubMed Central PMCID: PMC298900.
12. Gaczynska M, Rock KL, Goldberg AL. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature. 1993 Sep 16;365(6443):264-7. PubMed PMID 8396732.
13. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, et al…Goldberg AL. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9;78(5):761-71. PubMed PMID 8087844.
14. Palombella VJ, Rando OJ, Goldberg AL and Maniatis T. The ubiquitin- proteasome pathway is required for processing the NFkB1 precursor protein and the activation of NF-kB. Cell 1994; 78: 773-785.
15. Goldberg AL, Gaczynska M, Grant E, Michalek M, Rock KL. Functions of the proteasome in antigen presentation. Cold Spring Harb Symp Quant Biol. 1995;60:479-90. PubMed PMID 8824421.
16. Rock KL, Goldberg AL. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu Rev Immunol. 1999; 17: 739-79
17. Goldberg AL. Development of proteasome inhibitors as research tools and cancer drugs. J Cell Biol. 2012 Nov 12;199(4):583-8. PubMed PMID 23148232; PubMed Central PMCID: PMC3494858.
18. Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996;65:801-47. PubMed PMID 8811196.
19. Smith DM, Chang SC, Park S, Finley D, Cheng Y, et al. Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell. 2007 Sep 7;27(5):731-44. PubMed PMID 17803938; PubMed Central PMCID: PMC2083707.
20. Smith DM, Fraga H, Reis C, Kafri G, Goldberg AL. ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle. Cell. 2011 Feb 18;144(4):526-38. PubMed PMID 21335235; PubMed Central PMCID: PMC3063399.
21. Mitch WE, Goldberg AL. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med. 1996 Dec 19;335(25):1897-905. PubMed PMID 8948566.
22. Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, et al. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004 Jan;18(1):39-51. PubMed PMID 14718385.
23. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 2004 Apr 30;117(3):399-412. PubMed PMID 15109499; PubMed Central PMCID: PMC3619734.
24. Cohen S, Nathan JA, Goldberg AL. Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Discov. 2015 Jan;14(1):58-74. PubMed PMID 25549588.
25. Lokireddy, S, Kukushkin, NV, and Goldberg, AL. cAMP-induced phosphorylation of the 26S proteasome enhances its function and the degradation of misfolded proteins. Proc Natl Acad Sci USA. 2015 Dec 29; 112(52): E716-85. Doi 10.1073. PubMed PMID 1522332112.
26. VerPlank J, Lokireddy S, Zhao J, Goldberg AL. 26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation. Proc Natl Acad Sci U S A. 2019. doi:10.1073/pnas.1809254116. PMID 30782827.
27. VerPlank JJS, Tyrkalska SD, Fleming A, Rubinsztein DC, Goldberg AL. cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. Proc Natl Acad Sci U S A. 2020;117(25):14220-14230. doi:10.1073/pnas.2003277117. PMID 32513741.

References