Basaloid squamous cell lung carcinoma
Basaloid squamous cell lung carcinoma | |
---|---|
Specialty | Oncology |
Basaloid squamous cell carcinoma (Bas-SqCC) is an uncommon
Classification
Lung cancer is a large and exceptionally
Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992.[4]
In the third revision of the
Pathogenesis
Both basaloid and squamous cell carcinomas have been shown to arise from pre-malignant
Diagnosis
Like other forms of
In the case of Bas-SqCC, it is essential that both evidence of
Immunohistochemical markers that have been suggested to be useful in making an accurate diagnosis of Bas-SqCC include positivity for p63 and high molecular weight
Among other pulmonary malignancies, the main differential diagnoses in suspected cases of Bas-SqCC include the high-grade
Treatment
For last several decades of the 20th century, all histological variants of NSCLC were generally treated identically. In the last decade, it has become apparent that different variants of malignant tumors generally exhibit diverse genetic, biological, and clinical properties, including response to treatment.[12][13]
As patients with uncommon lung tumor variants, including tumors composed of mixtures of histological subtypes, tend to be excluded from
Prognosis
Like nearly all other forms of NSCLC, the prognosis of basaloid squamous cell carcinoma is quite poor.[16]
Although case numbers tend to be rather small, and the published studies
Epidemiology
The true incidence and prevalence of basaloid squamous cell lung carcinoma remains unknown, but this form of lung cancer is considered relatively uncommon.[17] In one of the largest studies of this particular variant, Moro-Sibilot and co-workers found a 6.3% prevalence of Bas-SqCC among 1,418 consecutive NSCLC patients at their institution.[7]
Basaloid carcinomas of the lung - like nearly all recognized variants of lung cancer - are highly associated with
As compared to other forms of lung cancer, Bas-SqCC often occurs in those who are somewhat older than average.[7] As SqCC is also associated with presentation at somewhat older ages, the true relevance/effect size of the basaloid-age interaction remains unknown.[citation needed]
Basaloid squamous cell carcinoma usually begins
References
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- ^ "Find NCI-Supported Clinical Trials". 2016-06-23.
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- ^ PMID 21269455.
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External links
- Lung Cancer Home Page. The National Cancer Institute site containing further reading and resources about lung cancer.
- [1]. World Health Organization Histological Classification of Lung and Pleural Tumours. 4th Edition.