Cadexomer iodine

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Cadexomer iodine
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Cadexomer iodine is an

epichlorhydrin coupled with ion-exchange groups and iodine. It is a water-soluble modified starch polymer containing 0.9% iodine, calculated on a weight-weight basis, within a helical matrix.[1]

History

Cadexomer iodine was developed in the early 1980s in Sweden by

Perstorp AB, and given the name Iodosorb. The product was shown to be effective in the treatment of venous ulcers,.[2][3]
More recently, it has been shown in studies in animals and humans that, unlike the iodophor
cicatrizant
.

Properties

When formulated as a topical wound dressing, Iodosorb adsorbs exudate and particulate matter from the surface of granulating wounds and, as the dressing becomes moist, iodine is released. The product thus has the dual effect of cleansing the wound and exerting a bactericidal action. The bactericidal mechanism of cadexomer iodine is effective against methicillin-resistant Staphylococcus aureus (MRSA) and may prevent MRSA proliferation in the wound bed.[5] This is especially significant because bacteria populations have shown no sign of developing a resistance to iodine since it was first used for wound treatment in the middle of the 19th century.[6]

Uses

In addition to other manufacturers, Smith & Nephew distributes cadexomer iodine as Iodosorb and Iodoflex in many countries of the world for the treatment and healing of various types of wounds. The dosage forms are a paste dressing, an ointment and a gel, all of which contain 0.9% iodine. It is available in India under brand name Cadomer and is sold by JB Chemicals.[7]

See also

References

  1. ^ Merck Index, 14th Edition, p262 Merck & Co. Inc.
  2. S2CID 6759410
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  3. .
  4. ^ Drosou A, Falabella A, Kirsner R (May 2003). "Antiseptics on wounds: an area of controversy. Wounds". 15 (5): 149–66. Retrieved 3 February 2009. {{cite journal}}: Cite journal requires |journal= (help)
  5. PMID 10037509
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  6. .
  7. ^ "Cadomer(Cadexomer Iodine)-Physician Information Page". Medical Dialogues. 21 August 2020. Retrieved 21 August 2020.