Eikenella corrodens

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Eikenella
Eikenella corrodens on chocolate agar after 36 hours. Notice how colonies pit the agar, which is a distinct characteristic of this species.
Scientific classification
Domain:
Phylum:
Class:
Order:
Neisseriales
Family:
Genus:
Eikenella
Species:
E. corrodens
Binomial name
Eikenella corrodens
(Eiken 1958) Jackson and Goodman 1972 (Approved Lists 1980)

Eikenella corrodens is a

commensal bacillus, capable of acting as an opportunistic pathogen and causing abscesses in several anatomical sites, including the liver, lung, spleen, and submandibular region.[4] E. corrodens could independently cause serious infection in both immunocompetent and immunocompromised hosts.[5]

Microbiology

Eikenella corrodens is a pleomorphic bacillus that sometimes appears coccobacillary and typically creates a depression (or "pit") in the agar on which it is growing. Only half produce the pitting of the agar considered characteristic.[citation needed]. It is a slow-growing, facultative anaerobe and a gram-negative bacillus.[6]

It grows in aerobic and anaerobic conditions, but requires an atmosphere enhanced by 3–10% carbon dioxide.[citation needed]

The colonies are small and greyish, they produce a greenish discoloration of the underlying agar, and smell faintly of bleach (hypochlorite).[citation needed]

They are oxidase-positive, catalase-negative, urease-negative, and indole-negative, and reduce nitrate to nitrite.[citation needed]

In 2006, Azakami et al reported that the periodontal pathogen E. corrodens has an

AI-2 synthesis and that E. corrodens can produce AI-2 signals for cell-to-cell communication. They additionally reported that AI-2 has a role in biofilm formation by E. corrodens.[7] Karim et al reported that this bacterium can produce AI-2 inactivation enzyme during its stationary phase.[8] Karim et al also reported that LuxS-mediated QS may facilitate the maturation and detachment of biofilm formation in E. corrodens, which can lead to progression of periodontal disease.[9]

Medical importance

Eikenella corrodens is a

HACEK group of infections which are a cause of culture-negative endocarditis. In general, the HACEK organisms are responsible for approximately 3% of all cases of infective endocarditis (IE). IE due to E. corrodens is usually a result of poor oral hygiene and or periodontal infection. Manipulation of the gingival or oral mucosa for dental procedures also can predispose patients to infection since E. corrodens is a constituent of the human oral flora.[13] E. corrodens can coexists and is frequently detected with other pathogens including Staphylococcus and Streptococcus.[14]

Eikenella corrodens infections are typically indolent (the infection does not become clinically evident until a week or more after the injury). They also mimic

anaerobic infection in being extremely foul-smelling.[citation needed
]

Eikenella corrodens was mentioned in an episode of Forensic Files, in which a hotel employee punched a woman in the mouth, knocking out two of her teeth. Her tooth bacteria caused a major infection in the man's hand.[15]

Treatment

For accurate diagnoses, a high degree of suspicion is required in order to properly attribute an infection to Eikenella corrodens.

fluoroquinolones (e.g., ciprofloxacin) in vitro, but no clinical evidence is available to advocate their use in these infections.[22]

References

External links